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Gut
IF
17.94
Papers
24337
Papers 24270
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Published on Mar 14, 2019in Gut 17.94
Lijun Liao2
Estimated H-index: 2
,
Kai Markus Schneider4
Estimated H-index: 4
(RWTH Aachen University)
+ 19 AuthorsPhilip Puchas1
Estimated H-index: 1
(University of Graz)
Objective There is a striking association between human cholestatic liver disease (CLD) and inflammatory bowel disease. However, the functional implications for intestinal microbiota and inflammasome-mediated innate immune response in CLD remain elusive. Here we investigated the functional role of gut–liver crosstalk for CLD in the murine Mdr2 knockout (Mdr2 −/− ) model resembling human primary sclerosing cholangitis (PSC). Design Male Mdr2 −/− , Mdr2 −/− crossed with hepatocyte-specific deletio...
1 Citations Source Cite
Published on Nov 17, 2018in Gut 17.94
Morgane Cheminant2
Estimated H-index: 2
,
Julie Bruneau39
Estimated H-index: 39
+ 25 AuthorsLudovic Lhermitte15
Estimated H-index: 15
Objectives Primary GI T-cell lymphoproliferative diseases (T-LPD) are heterogeneous entities, which raise difficult diagnosis and therapeutic challenges. We have recently provided evidences that lymphomas complicating coeliac disease (CD) arise from innate-like lymphocytes, which may carry NK receptors (NKRs). Design NKRs expression was compared by flow cytometry in intraepithelial lymphocytes (IEL) from CD, type I or type II refractory CD (RCD). NKp46 was next assessed by immunohistochemistry i...
1 Citations Source Cite
Published on Nov 28, 2018in Gut 17.94
Upkar S. Gill14
Estimated H-index: 14
(QMUL: Queen Mary University of London),
Laura J. Pallett8
Estimated H-index: 8
(UCL: University College London)
+ 5 AuthorsMala K. Maini37
Estimated H-index: 37
(UCL: University College London)
Objective In order to refine new therapeutic strategies in the pipeline for HBV cure, evaluation of virological and immunological changes compartmentalised at the site of infection will be required. We therefore investigated if liver fine needle aspirates (FNAs) could comprehensively sample the local immune landscape in parallel with viable hepatocytes. Design Matched blood, liver biopsy and FNAs from 28 patients with HBV and 15 without viral infection were analysed using 16-colour multiparamete...
1 Citations Source Cite
Published on Apr 26, 2019in Gut 17.94
Patrice D. Cani76
Estimated H-index: 76
(UCL: Université catholique de Louvain)
Increased intake of dietary fibre has been linked to beneficial impacts on health for decades. Strikingly, the exact mechanisms of action are not yet fully understood. Among the different families of fibres, prebiotics have gained attention mainly because of their capacity to selectively modulate the gut microbiota composition and promote health benefits.1 Prebiotics are fermented by gut bacteria into short-chain fatty acids (SCFA) such as acetate, butyrate and propionate, but multiple other met...
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Published on Oct 30, 2018in Gut 17.94
Hongda Chen10
Estimated H-index: 10
(Peking Union Medical College),
Ni Li11
Estimated H-index: 11
(Peking Union Medical College)
+ 13 AuthorsShuangmei Zou (Peking Union Medical College)
Objective Colorectal cancer (CRC) screening has been widely implemented in many countries. However, evidence on participation and diagnostic yield of population-based CRC screening in China is sparse. Design The analyses were conducted in the context of the Cancer Screening Program in Urban China, which recruited 1 381 561 eligible participants aged 40–69 years from 16 provinces in China from 2012 to 2015. 182 927 participants were evaluated to be high risk for CRC by an established risk score s...
1 Citations Source Cite
Published on Apr 10, 2019in Gut 17.94
Edward S. Chambers15
Estimated H-index: 15
(Imperial College London),
Claire S Byrne3
Estimated H-index: 3
(Imperial College London)
+ 17 AuthorsElaine Holmes101
Estimated H-index: 101
(Imperial College London)
Objective To investigate the underlying mechanisms behind changes in glucose homeostasis with delivery of propionate to the human colon by comprehensive and coordinated analysis of gut bacterial composition, plasma metabolome and immune responses. Design Twelve non-diabetic adults with overweight and obesity received 20 g/day of inulin-propionate ester (IPE), designed to selectively deliver propionate to the colon, a high-fermentable fibre control (inulin) and a low-fermentable fibre control (ce...
1 Citations Source Cite
Published on Jul 11, 2018in Gut 17.94
Romaric Loffroy1
Estimated H-index: 1
,
Marc Bardou29
Estimated H-index: 29
We read with great interest the article by Lau et al recently published in Gut and evaluating the role of prophylactic angiographic arterial embolisation performed after achieved endoscopic haemostasis in the management of patients with high-risk ulcer bleeding.1 We have several comments. First of all, we would like to congratulate the authors for their study which represents the largest multicentre randomised controlled trial to date reporting results of additional embolisation in selected high...
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Published on Jul 27, 2018in Gut 17.94
Ren Mao , Yu-jun Chen4
Estimated H-index: 4
(SYSU: Sun Yat-sen University)
+ 1 AuthorsMinhu Chen30
Estimated H-index: 30
(SYSU: Sun Yat-sen University)
We read with great interest a recent review by Bryant et al 1 presenting a pragmatic guide of GI ultrasound (GIUS) in IBD clinical practice. We agree with the authors that the uptake of GIUS outside Europe has been slow and GIUS is underused in many countries. Here we would like to introduce the status, challenge and opportunity of GIUS implementation in IBD clinical practice in a different region of the world, namely China. We have witnessed a striking increase in the incidence of IBD in China ...
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Published on Nov 24, 2018in Gut 17.94
Nathalie Stakenborg8
Estimated H-index: 8
(Katholieke Universiteit Leuven),
Evelien Labeeuw3
Estimated H-index: 3
(Katholieke Universiteit Leuven)
+ 25 AuthorsMichelle Stakenborg4
Estimated H-index: 4
(Katholieke Universiteit Leuven)
Objectives Vagus nerve stimulation (VNS), most likely via enteric neurons, prevents postoperative ileus (POI) by reducing activation of alpha7 nicotinic receptor (α7nAChR) positive muscularis macrophages (mMφ) and dampening surgery-induced intestinal inflammation. Here, we evaluated if 5-HT4 receptor (5-HT4R) agonist prucalopride can mimic this effect in mice and human. Design Using Ca 2+ imaging, the effect of electrical field stimulation (EFS) and prucalopride was evaluated in situ on mMφ acti...
5 Citations Source Cite
Published on May 10, 2019in Gut 17.94
Michael Camilleri105
Estimated H-index: 105
(Mayo Clinic)
The objectives of this review on ‘leaky gut’ for clinicians are to discuss the components of the intestinal barrier, the diverse measurements of intestinal permeability, their perturbation in non-inflammatory ‘stressed states’ and the impact of treatment with dietary factors. Information on ‘healthy’ or ‘leaky’ gut in the public domain requires confirmation before endorsing dietary exclusions, replacement with non-irritating foods (such as fermented foods) or use of supplements to repair the dam...
2 Citations Source Cite
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