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#1Lin Wang (PKU: Peking University)H-Index: 8
#2Zhe Zhang (PKU: Peking University)H-Index: 4
Last. L. Wang (PKU: Peking University)H-Index: 73
view all 12 authors...
Hepatitis E virus (HEV) RNA has been recently discovered in semen samples of Chinese infertile man with a remarkably high rate of 28.1% (52/185, table 1).1 All HEV isolates belong to HEV genotype 4 (HEV4), which is the dominant strain prevalent in China. This intriguing discovery has aroused our attention. In a recent response to the work done by Huang et al , researchers in Germany tested 87 semen samples collected from infertile men, but the HEV RNA positive rate is 0% (table 1).2 Germany is p...
1 CitationsSource
#1Konstantinos Papamichael (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 22
#2Adam S. Cheifetz (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 36
Last. Peter M. IrvingH-Index: 38
view all 3 authors...
Antitumour necrosis factor (anti-TNF) therapy has revolutionised the treatment of moderate to severe inflammatory bowel disease (IBD). However, up to 30% of patients with Crohn’s disease (CD) and ulcerative colitis (UC) do not respond to anti-TNF therapy, often referred to as primary non-responders. Additionally, almost 50% of patients who initially respond to anti-TNF lose response over time, a phenomenon known as secondary loss of response (SLR).1 Both of these negative outcomes are most commo...
1 CitationsSource
#1Patrick P Weil (Witten/Herdecke University)H-Index: 4
#2Rhea van den BruckH-Index: 2
Last. Jan Postberg (Witten/Herdecke University)H-Index: 20
view all 9 authors...
We read with interest the recent work by Schleier et al 1 demonstrating consequences of impaired α4β7 integrin-dependent gut homing of intestinal macrophages on wound healing, which fits well with own observations we have made in a case of congenital infantile intractable diarrhoea linked to impaired integrin receptors in intestinal epithelia (αVβ6). Specifically, a male dizygotic twin was delivered dystrophic (1715 g) at 36 weeks of gestational age and developed intractable diarrhoea within the...
#1Jinfeng Wang (CAS: Chinese Academy of Sciences)H-Index: 13
#2Zhen Jia (CAS: Chinese Academy of Sciences)H-Index: 2
Last. Fangqing ZhaoH-Index: 34
view all 5 authors...
With great interest we read the article by Gaiser et al 1 that enrichment of oral bacterial taxa in pancreatic cancer highlights the role of oral microbiota. Not coincidentally, the presence of Fusobacterium nucleatum in paired saliva and colon samples of the patients with colorectal cancer has been reported,2 3 raising interest in whether disease starts in the mouth or in the intestine.4–6 Another reason people are interested in oral microbes is their potentials serving as biomarkers for system...
2 CitationsSource
#1Lisa Olsson (University of Gothenburg)H-Index: 4
#2Christine PoitouH-Index: 39
Last. Robert Caesar (University of Gothenburg)H-Index: 16
view all 8 authors...
Objective The gut microbiota has been implicated in the aetiology of obesity and associated comorbidities. Patients with Prader-Willi syndrome (PWS) are obese but partly protected against insulin resistance. We hypothesised that the gut microbiota of PWS patients differs from that of non-genetically obese controls and correlate to metabolic health. Therefore, here we used PWS as a model to study the role of gut microbiota in the prevention of metabolic complications linked to obesity. Design We ...
1 CitationsSource
#1Sunbin LingH-Index: 4
#2Qiaonan ShanH-Index: 5
Last. Xiao XuH-Index: 24
view all 25 authors...
Objective We aimed to elucidate the mutual regulation mechanism of ubiquitin-specific protease 22 (USP22) and hypoxia inducible factor-1?? (HIF1??), and the mechanism they promote the stemness of hepatocellular carcinoma (HCC) cells under hypoxic conditions. Design Cell counting, migration, self-renewal ability, chemoresistance and expression of stemness genes were established to detect the stemness of HCC cells. Immunoprecipitation, ubiquitination assay and chromatin immunoprecipitation assay w...
2 CitationsSource
#1Jessie Qiaoyi Liang (CUHK: The Chinese University of Hong Kong)H-Index: 3
#2Tong Li (CUHK: The Chinese University of Hong Kong)H-Index: 3
Last. Jun Yu (CUHK: The Chinese University of Hong Kong)H-Index: 83
view all 13 authors...
Objective There is a need for early detection of colorectal cancer (CRC) at precancerous-stage adenoma. Here, we identified novel faecal bacterial markers for diagnosing adenoma. Design This study included 1012 subjects (274 CRC, 353 adenoma and 385 controls) from two independent Asian groups. Candidate markers were identified by metagenomics and validated by targeted quantitative PCR. Results Metagenomic analysis identified ‘m3’ from a Lachnoclostridium sp., Fusobacterium nucleatum (Fn) and Clo...
3 CitationsSource
#1Qiang Wang (NU: Nanjing University)H-Index: 2
#2Chen Chen (Nanjing Medical University)H-Index: 1
Last. Shouyu WangH-Index: 16
view all 14 authors...
Objective N6-methyladenosine (m6A) RNA methylation and its associated methyltransferase METTL3 are involved in tumour initiation and progression via the regulation of RNA function. This study explored the biological function and clinical significance of METTL3 in gastric cancer (GC). Design The prognostic value of METTL3 expression was evaluated using tissue microarray and immunohistochemical staining analyses in a human GC cohort. The biological role and mechanism of METTL3 in GC tumour growth ...
28 CitationsSource
#1Victoria Meslier (Université Paris-Saclay)H-Index: 1
#2Manolo Laiola (University of Naples Federico II)H-Index: 4
Last. Nicolas Pons (Université Paris-Saclay)H-Index: 26
view all 16 authors...
Objectives This study aimed to explore the effects of an isocaloric Mediterranean diet (MD) intervention on metabolic health, gut microbiome and systemic metabolome in subjects with lifestyle risk factors for metabolic disease. Design Eighty-two healthy overweight and obese subjects with a habitually low intake of fruit and vegetables and a sedentary lifestyle participated in a parallel 8-week randomised controlled trial. Forty-three participants consumed an MD tailored to their habitual energy ...
8 CitationsSource
Top fields of study
Diabetes mellitus