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#1Benjamin H. Mullish (Imperial College London)H-Index: 5
#2Julie A. McDonald (Imperial College London)H-Index: 9
Last.Cormac G. M. Gahan (UCC: University College Cork)H-Index: 51
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Objective Faecal microbiota transplant (FMT) effectively treats recurrent Clostridioides difficile infection (rCDI), but its mechanisms of action remain poorly defined. Certain bile acids affect C. difficile germination or vegetative growth. We hypothesised that loss of gut microbiota-derived bile salt hydrolases (BSHs) predisposes to CDI by perturbing gut bile metabolism, and that BSH restitution is a key mediator of FMT’s efficacy in treating the condition. Design Using stool collected from pa...
#1Giacomo Puppa (Geneva College)H-Index: 10
#2Yann Christinat (Geneva College)
Last.Thomas Alexander Mckee (Geneva College)H-Index: 17
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We read with interest the paper by Singhi et al .1 The authors prospectively assessed using targeted next-generation sequencing (NGS) 626 pancreatic cyst fluid (PCF) samples from 595 patients. They found that compared with Sanger sequencing, cytology and CEA, preoperative NGS for KRAS/GNAS mutations is highly sensitive for intraductal papillary mucinous neoplasms (IPMNs) and specific for mucinous pancreatic cysts (PCs). Moreover, alterations in TP53/PIK3/PTEN are significantly associated with ad...
#1Vishal Singh (UT: University of Toledo)H-Index: 16
#2Beng San Yeoh (PSU: Pennsylvania State University)H-Index: 10
Last.Qing Liu (PSU: Pennsylvania State University)H-Index: 1
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Objective Diets rich in fermentable fibres provide an array of health benefits; however, many patients with IBD report poor tolerance to fermentable fibre-rich foods. Intervention studies with dietary fibres in murine models of colonic inflammation have yielded conflicting results on whether fibres ameliorate or exacerbate IBD. Herein, we examined how replacing the insoluble fibre, cellulose, with the fermentable fibres, inulin or pectin, impacted murine colitis resulting from immune dysregulati...
#1Cyrielle Caussy (University of Lyon)H-Index: 8
#2Veeral AjmeraH-Index: 8
Last.Emily RizoH-Index: 5
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Objective Non-invasive and accurate diagnostic tests for the screening of disease severity in non-alcoholic fatty liver disease (NAFLD) remain a major unmet need. Therefore, we aimed to examine if a combination of serum metabolites can accurately predict the presence of advanced fibrosis. Design This is a cross-sectional analysis of a prospective derivation cohort including 156 well-characterised patients with biopsy-proven NAFLD and two validation cohorts, including (1) 142 patients assessed us...
#1Duowei Wang (CPU: China Pharmaceutical University)H-Index: 4
#2Xianjing Li (CPU: China Pharmaceutical University)H-Index: 6
Last.Shuran Li (CPU: China Pharmaceutical University)H-Index: 1
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Objective APOBEC3B (A3B), a cytidine deaminase acting as a contributor to the APOBEC mutation pattern in many kinds of tumours, is upregulated in patients with hepatocellular carcinoma (HCC). However, APOBEC mutation patterns are absent in HCC. The mechanism of how A3B affects HCC progression remains elusive. Design A3B ­promoter luciferase reporter and other techniques were applied to elucidate mechanisms of A3B upregulation in HCC. A3B overexpression and knockdown cell models, immunocompetent ...
#1Silvio DaneseH-Index: 64
#2Marjorie ArgolloH-Index: 3
Last.Laurent Peyrin-Biroulet (French Institute of Health and Medical Research)H-Index: 57
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The two major forms of inflammatory bowel disease (IBD), encompassing Crohn’s disease (CD) and ulcerative colitis (UC), are chronic immune-mediated conditions characterised by an increased production of pro-inflammatory cytokines that act as critical drivers of intestinal inflammation. Anti-cytokine therapy has been shown to improve clinical outcomes in IBD. Janus kinases (JAKs) are tyrosine kinases that bind different intracellular cytokine receptors, leading to phosphorylation of signal transd...
#2Peter R. Gibson (Monash University)H-Index: 57
We read the randomised controlled trial (RCT) by Zhou et al. 1 The authors recruited a highly selected group of patients with increased intestinal permeability and postinfection IBS with diarrhoea (IBS-D), defined by an unconfirmed enteric infection in the 12 months prior to symptom onset, and randomised them to 8 weeks of treatment with either glutamine or placebo. The population screened also had other curious features. For example, only four had rapid orocaecal transit on lactulose hydrogen b...
#1Pu Wang (Academy of Medical Sciences, United Kingdom)H-Index: 1
#2Tyler M. Berzin (BIDMC: Beth Israel Deaconess Medical Center)H-Index: 17
Last.Di Zhang (Academy of Medical Sciences, United Kingdom)H-Index: 1
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Objective The effect of colonoscopy on colorectal cancer mortality is limited by several factors, among them a certain miss rate, leading to limited adenoma detection rates (ADRs). We investigated the effect of an automatic polyp detection system based on deep learning on polyp detection rate and ADR. Design In an open, non-blinded trial, consecutive patients were prospectively randomised to undergo diagnostic colonoscopy with or without assistance of a real-time automatic polyp detection system...
#1Chao Lin (Fudan University)H-Index: 5
#2Hongyong He (Fudan University)H-Index: 7
Last.Heng Zhang (Fudan University)H-Index: 8
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Objective Our previous studies have identified CXCL8 as the crucial chemokine responsible for gastric cancer metastasis mediated by loss of RACK1. However, the regulatory effect of CXCL8 on immune surveillance in gastric cancer remains obscure. Design Flow cytometry analyses were performed to examine major source of CXCL8 and phenotypes of immune cells in fresh tumour tissues from 76 patients with gastric cancer. Real-time PCR was performed to analyse CXCL8 mRNA level in gastric cancer tissues. ...
#1Marzieh SalehiH-Index: 13
#2Marzieh SalehiH-Index: 2
Last.David D’Alessio (University of Cincinnati Academic Health Center)H-Index: 9
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Objective Postprandial hyperinsulinaemia after Roux-en Y gastric bypass (GB) has been attributed to rapid nutrient flux from the gut, and an enhanced incretin effect. However, it is unclear whether surgery changes islet cell responsiveness to regulatory factors. This study tested the hypothesis that β-cell sensitivity to glucagon like-peptide 1 (GLP-1) and glucose-dependent insulinotropic peptide (GIP) is attenuated after GB. Design Ten non-diabetic subjects with GB, and 9 body mass index (BMI)-...
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