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#1Balázs NémethH-Index: 10
#2Anna Orekhova (BU: Boston University)
Last. Maisam Abu-El-HaijaH-Index: 11
view all 7 authors...
We read the publication written by Lin et al 1 with great interest. The authors suggest that the majority of functionally defective carboxypeptidase A1 ( CPA1) mutations can elicit reduced expression due to nonsense-mediated decay (NMD) and therefore, only a small subset of the earlier reported CPA1 variants2 will predispose to chronic pancreatitis (CP) via the misfolding-dependent pathway.3 This paper seemingly offered an explanation for the earlier finding of Wu et al 4 where the authors repor...
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#1Neal ShahidiH-Index: 12
#2Mayenaaz SidhuH-Index: 4
Last. Michael J. BourkeH-Index: 36
view all 12 authors...
Objective The optimal approach for removing large laterally spreading lesions at the anorectal junction (ARJ-LSLs) is unknown. Endoscopic mucosal resection (EMR) is a definitive therapy for colorectal LSLs. It is unclear whether it is an effective modality for ARJ-LSLs. Design EMR outcomes for ARJ-LSLs (distal margin of ≤20 mm from the dentate line) in comparison with rectal LSLs (distal margin of >20 mm from the dentate line) were evaluated within a multicentre observational cohort of LSLs of ≥...
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#1Rooshi Nathwani (Imperial College London)H-Index: 1
#2Benjamin H. Mullish (Imperial College London)H-Index: 7
Last. A. Dhar (Imperial College London)H-Index: 6
view all 5 authors...
A 43-year-old man presented to the hospital with septic shock. Eight weeks prior, he had experienced recurrent gastric variceal bleeding (figure 1), treated initially with cyanoacrylate glue injection. Abdominal CT scan suggested features of chronic liver disease, with non-alcoholic fatty liver disease being the presumed aetiology. Despite endoscopic therapy, he had further variceal haemorrhage, and was treated successfully with insertion of a transjugular intrahepatic portosystemic stent shunt ...
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#1Jin-Huan Lin (French Institute of Health and Medical Research)H-Index: 5
#2Arnaud Boulling (French Institute of Health and Medical Research)H-Index: 7
Last. Jian-Min Chen (French Institute of Health and Medical Research)H-Index: 40
view all 8 authors...
We have read with interest the recent publication of Hegyi and Sahin-Toth1 reporting that chronic pancreatitis (CP)-predisposing CPA1 mutations function through the misfolding pathway rather than through loss of CPA1 protein/activity. Herein, we explore an additional insight gleaned from this study beyond those discussed in an accompanying Editorial.2 In the original study reporting the association of CPA1 variants with CP, all unambiguous loss-of-function (LoF) variants (eg, nonsense mutations)...
1 CitationsSource
#1Erin L. SymondsH-Index: 16
#2Kathryn Cornthwaite (Flinders University)H-Index: 1
Last. Graeme P. Young (Flinders University)H-Index: 47
view all 6 authors...
We read with interest the article by Cross et al ,1 which examined the use of FIT in intermediate risk patients undergoing 3 yearly surveillance colonoscopies. The investigators assessed the diagnostic accuracy of this approach, together with the number of advanced adenomas and colorectal cancers missed, and the potential cost savings. The results indicate that replacing 3 yearly colonoscopy with annual FIT (with a positivity threshold of 40 µg Hb/g faeces) would result in cost savings over the ...
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#1Tiziana La BellaH-Index: 2
#2Sandrine ImbeaudH-Index: 43
Last. Jessica Zucman-RossiH-Index: 64
view all 21 authors...
Objective Adeno-associated virus (AAV) is a defective mono-stranded DNA virus, endemic in human population (35%–80%). Recurrent clonal AAV2 insertions are associated with the pathogenesis of rare human hepatocellular carcinoma (HCC) developed on normal liver. This study aimed to characterise the natural history of AAV infection in the liver and its consequence in tumour development. Design Viral DNA was quantified in tumour and non-tumour liver tissues of 1461 patients. Presence of episomal form...
1 CitationsSource
#1Peter BossuytH-Index: 14
#2Severine Vermeire (Universitaire Ziekenhuizen Leuven)H-Index: 110
Last. Raf Bisschops (Universitaire Ziekenhuizen Leuven)H-Index: 29
view all 3 authors...
With great interest we read the review article of Iacucci et al on advanced endoscopic techniques in IBD.1 The authors clearly recognise the current limitations of the different endoscopic scoring tools for disease activity in IBD and provide potential solutions with new advanced techniques. We fully agree that interobserver variability is problematic for treatment planning and IBD drug development and we lack objective definitions of endoscopic remission that predict further disease course in b...
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#1Philip J. Smith (Royal Free London NHS Foundation Trust)H-Index: 1
### Manipulation of the gut microbiome to treat alcoholic hepatitis Duan Y, Llorente C, Lang S, et al . Bacteriophage targeting of gut bacterium attenuates alcoholic liver disease. Nature 2019;575:505–511. Alcoholic hepatitis (AH) is a severe manifestation of alcohol-associated liver disease with limited therapeutic options and a high associated mortality. While perturbation of the gut microbiota and gut barrier dysfunction have been previously associated with AH, their specific contribution to ...
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#1Ningning Niu (SJTU: Shanghai Jiao Tong University)H-Index: 1
#2Ping Lu (SJTU: Shanghai Jiao Tong University)H-Index: 2
Last. Jing Xue (SJTU: Shanghai Jiao Tong University)H-Index: 9
view all 16 authors...
Objective SETD2, the sole histone H3K36 trimethyltransferase, is frequently mutated or deleted in human cancer, including pancreatic ductal adenocarcinoma (PDAC). However, whether SETD2/H3K36me3 alteration results in PDAC remains largely unknown. Design TCGA(PAAD) public database and PDAC tissue array with SETD2/H3K36me3 staining were used to investigate the clinical relevance of SETD2 in PDAC. Furthermore, to define the role of SETD2 in the carcinogenesis of PDAC, we crossed conditional Setd2 k...
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#1Alanna Ebigbo (Augsburg College)H-Index: 6
#2Robert MendelH-Index: 3
Last. Helmut Messmann (Augsburg College)H-Index: 38
view all 9 authors...
Based on previous work by our group with manual annotation of visible Barrett oesophagus (BE) cancer images, a real-time deep learning artificial intelligence (AI) system was developed. While an expert endoscopist conducts the endoscopic assessment of BE, our AI system captures random images from the real-time camera livestream and provides a global prediction (classification), as well as a dense prediction (segmentation) differentiating accurately between normal BE and early oesophageal adenoca...
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Endocrinology
Surgery
Diabetes mellitus
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