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Published on Jan 3, 2019in Gut 17.02
Philip R. Harvey1
Estimated H-index: 1
,
Ben Coupland1
Estimated H-index: 1
(Queen Elizabeth Hospital Birmingham)
+ 3 AuthorsNigel Trudgill15
Estimated H-index: 15
Introduction Achalasia is a disorder characterised by failed relaxation of the lower oesophageal sphincter. The aim of this study was to examine, at a national level, the long-term outcomes of achalasia therapies. Methods Hospital Episode Statistics include diagnostic and procedural data for all English National Health Service–funded hospital admissions. Subjects with a code for achalasia who had their initial treatment between January 2006 and December 2015 were grouped by treatment; pneumatic ...
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Published on Jan 19, 2019in Gut 17.02
Clemens Schafmayer29
Estimated H-index: 29
(University of Kiel),
James Harrison6
Estimated H-index: 6
(University of Exeter)
+ 60 AuthorsBodo Schniewind23
Estimated H-index: 23
Objective Diverticular disease is a common complex disorder characterised by mucosal outpouchings of the colonic wall that manifests through complications such as diverticulitis, perforation and bleeding. We report the to date largest genome-wide association study (GWAS) to identify genetic risk factors for diverticular disease. Design Discovery GWAS analysis was performed on UK Biobank imputed genotypes using 31 964 cases and 419 135 controls of European descent. Associations were replicated in...
1 Citations Source Cite
Published on Mar 14, 2019in Gut 17.02
Lijun Liao2
Estimated H-index: 2
,
Kai Markus Schneider4
Estimated H-index: 4
(RWTH Aachen University)
+ 19 AuthorsPhilip Puchas (University of Graz)
Objective There is a striking association between human cholestatic liver disease (CLD) and inflammatory bowel disease. However, the functional implications for intestinal microbiota and inflammasome-mediated innate immune response in CLD remain elusive. Here we investigated the functional role of gut–liver crosstalk for CLD in the murine Mdr2 knockout (Mdr2 −/− ) model resembling human primary sclerosing cholangitis (PSC). Design Male Mdr2 −/− , Mdr2 −/− crossed with hepatocyte-specific deletio...
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Published on Apr 1, 2019in Gut 17.02
Joren R. ten Hove2
Estimated H-index: 2
(Utrecht University),
Shailja Shah5
Estimated H-index: 5
+ 21 AuthorsJason Glass1
Estimated H-index: 1
(Icahn School of Medicine at Mount Sinai)
Objectives Surveillance colonoscopy is thought to prevent colorectal cancer (CRC) in patients with long-standing colonic IBD, but data regarding the frequency of surveillance and the findings thereof are lacking. Our aim was to determine whether consecutive negative surveillance colonoscopies adequately predict low neoplastic risk. Design A multicentre, multinational database of patients with long-standing IBD colitis without high-risk features and undergoing regular CRC surveillance was constru...
1 Citations Source Cite
Published on Feb 1, 2019in Gut 17.02
Philip W. Chiu27
Estimated H-index: 27
(The Chinese University of Hong Kong),
Noriya Uedo35
Estimated H-index: 35
+ 12 AuthorsFang Yao1
Estimated H-index: 1
(Academy of Medical Sciences, United Kingdom)
Background This is a consensus developed by a group of expert endoscopists aiming to standardise the preparation, process and endoscopic procedural steps for diagnosis of early upper gastrointestinal (GI) cancers. Method The Delphi method was used to develop consensus statements through identification of clinical questions on diagnostic endoscopy. Three consensus meetings were conducted to consolidate the statements and voting. We conducted a systematic literature search on evidence for each sta...
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Published on Feb 1, 2019in Gut 17.02
Zhonghu He12
Estimated H-index: 12
(Peking University),
Zhen Liu2
Estimated H-index: 2
(Peking University)
+ 13 AuthorsQi Wu1
Estimated H-index: 1
(Peking University)
Objective Description of the design and preliminary results of baseline recruitment and screening in the endoscopic screening for esophageal cancer in China (ESECC), the first randomised controlled trial (RCT) assessing efficacy and cost-effectiveness of endoscopic screening for esophageal squamous cell carcinoma (ESCC). Design ESECC trial is a cluster RCT, and 668 villages in rural Hua County, Henan Province, a high-incidence area of ESCC in China, were randomised into two arms at a ratio of 1:...
2 Citations Source Cite
Published on Jan 22, 2019in Gut 17.02
Maria Gloria Dominguez-Bello27
Estimated H-index: 27
(Rutgers University),
Filipa Godoy-Vitorino8
Estimated H-index: 8
(University of Puerto Rico)
+ 1 AuthorsMartin J. Blaser116
Estimated H-index: 116
(New York University)
The host-microbiome supraorganism appears to have coevolved and the unperturbed microbial component of the dyad renders host health sustainable. This coevolution has likely shaped evolving phenotypes in all life forms on this predominantly microbial planet. The microbiota seems to exert effects on the next generation from gestation, via maternal microbiota and immune responses. The microbiota ecosystems develop, restricted to their epithelial niches by the host immune system, concomitantly with ...
1 Citations Source Cite
Published on Apr 1, 2019in Gut 17.02
Ausilia Enea1
Estimated H-index: 1
(University of Turin),
Antonio Pizzol2
Estimated H-index: 2
(University of Turin)
+ 4 AuthorsPier Luigi Calvo13
Estimated H-index: 13
(University of Turin)
We read with interest the letter by Nemeth et al ,1 describing a hereditary pancreatitis (HP) family of Hungarian origin carrying the heterozygous p.Leu104Pro variant of human cationic trypsinogen (PRSS1) gene. It added further data to previous publications by Schnur et al 2 and Balazs et al ,3 who proposed that a subset of PRSS1 variants caused chronic pancreatitis by inducing misfolding and endoplasmic reticulum stress, rather than increased intrapancreatic trypsin activity. However, a clinica...
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Published on Mar 1, 2019in Gut 17.02
Robert Schierwagen14
Estimated H-index: 14
(University of Bonn),
Camila Alvarez-Silva1
Estimated H-index: 1
(University of Copenhagen)
+ 14 AuthorsAlessandra Pohlmann5
Estimated H-index: 5
(University of Bonn)
We read with interest the recent review by Tilg et al ,1 which summarised the role of microbiota in liver diseases and pointed out that a causal link with systemic inflammation has still not been established. This letter fills in this gap and provides an analysis of the circulating microbiota in portal vein as the link between gut and liver. The access to portal circulation is possible during the implantation of a transjugular intrahepatic portosystemic shunt (TIPS). Therefore, we characterised ...
7 Citations Source Cite
Published on Mar 14, 2019in Gut 17.02
Rogier Gaiser (Karolinska Institutet), Asif Halimi1
Estimated H-index: 1
+ 9 AuthorsCarlos Fernández Moro4
Estimated H-index: 4
Objectives Intraductal papillary mucinous neoplasms (IPMNs) are pancreatic cysts that can progress to invasive pancreatic cancer. Associations between oncogenesis and oral microbiome alterations have been reported. This study aims to investigate a potential intracystic pancreatic microbiome in a pancreatic cystic neoplasm (PCN) surgery patient cohort. Design Paired cyst fluid and plasma were collected at pancreatic surgery from patients with suspected PCN (n=105). Quantitative and qualitative as...
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