Review paper
Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy
Abstract
Takayasu arteritis (TAK) and giant cell arteritis (GCA) affect mainly large- and medium-sized arteries. In refractory cases, vascular remodeling progresses and leads to serious outcomes. Studies have demonstrated that cytokines such as interleukin (IL)-6 play crucial roles in the pathophysiology of TAK and GCA. Recently, randomized controlled trials on IL-6 inhibition therapy using tocilizumab (TCZ) were performed, and significant effects were...
Paper Details
Title
Pathophysiology of large vessel vasculitis and utility of interleukin-6 inhibition therapy
Published Date
Feb 4, 2019
Journal
Volume
29
Issue
2
Pages
287 - 293
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