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Nanoencapsulation of caffeic acid phenethyl ester in sucrose fatty acid esters to improve activities against cancer cells

Published on Apr 1, 2019in Journal of Food Engineering 3.20
· DOI :10.1016/j.jfoodeng.2018.11.008
Yongguang Guan11
Estimated H-index: 11
(University of Tennessee),
Huaiqiong Chen11
Estimated H-index: 11
(University of Tennessee),
Qixin Zhong31
Estimated H-index: 31
(University of Tennessee)
Abstract
Abstract Caffeic acid phenethyl ester (CAPE) is a natural compound with anticancer activities but has low water solubility. In this work, sucrose fatty acid ester (SFAE) was used to nanoencapsulate CAPE in aqueous propylene glycol (PG) with a temperature-cycle method by heating at 90 °C for 20 min and cooling to 21 °C, followed by additional heating at 90 °C for 5 min and cooling to 21 °C. A higher amount of PG facilitated encapsulation with up to 0.1%w/w CAPE in 1.0% w/w SFAE. Additional 0.3%w/w thymol further improved the CAPE loading capability to 0.15%w/w to form nanoparticles smaller than 100 nm and stable in 30 days at 21 °C. Nanoencapsulation enhanced cytotoxicity of CAPE against colon cancer HCT-116 and breast cancer MCF-7 cells, and thymol additionally enhanced the cytotoxicity of CAPE dispersions. This work provides a new approach to nanoencapsulate CAPE in stable aqueous dispersions with improved cytotoxicity.
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Published on Jun 20, 2018in Journal of Agricultural and Food Chemistry 3.41
Tulin Arasoglu4
Estimated H-index: 4
,
Serap Derman5
Estimated H-index: 5
In the present study, the antigenotoxic activity of poly(d,l-lactic-co-glycolic acid) (PLGA) nanoparticles (NPs) loaded with caffeic acid phenethyl ester (CAPE) was investigated in comparison to free CAPE using the Ames Salmonella/microsome assay. Additionally, to elucidate the impacts of the type of solvent effect on antigenotoxic activity, the following systems were tested: CAPE in water (poor solvent), ethyl alcohol (good solvent), and PLGA NPs (unknown). The effect of the NP system on solubi...
1 Citations Source Cite
Published on Oct 1, 2016in Advances in Colloid and Interface Science 7.35
Stefan Wolfrum2
Estimated H-index: 2
(University of Regensburg),
Julien Marcus8
Estimated H-index: 8
(University of Regensburg)
+ 1 AuthorsWerner Kunz44
Estimated H-index: 44
(University of Regensburg)
Abstract Soaps are the oldest and perhaps most natural surfactants. However, they lost much of their importance since “technical surfactants”, usually based on sulfates or sulfonates, have been developed over the last fifty years. Indeed, soaps are pH- and salt-sensitive and they are irritant, especially to the eyes. In food emulsions, although authorized, they have a bad taste, and long-chain saturated soaps have a high Krafft temperature. We believe that most or perhaps all of these problems c...
7 Citations Source Cite
Published on Apr 1, 2016in Scientific Reports 4.12
Jianfu Li13
Estimated H-index: 13
,
Rui-Qin Zhang26
Estimated H-index: 26
Orbital interaction theory, which provides a comprehensive model for examining the structures and kinetic and thermodynamic stability of molecules, has made a great contribution to our understanding of the fundamental processes in chemistry1. Atomic orbitals form molecular orbitals through overlap which leads to a lower energy state of the system. The two new orbitals which are formed from the interaction of two atomic orbitals are the bonding orbital and the antibonding orbital. The energy of t...
9 Citations Source Cite
Published on Mar 1, 2015in Food Chemistry 4.95
Marrisa Guttoff1
Estimated H-index: 1
(University of Massachusetts Amherst),
Amir Hossein Saberi14
Estimated H-index: 14
(University of Massachusetts Amherst),
D. Julian McClements108
Estimated H-index: 108
(University of Massachusetts Amherst)
abstract Oil-in-water nanoemulsions are particularly suitable for encapsulation of lipophilic nutraceuticalsbecause of their ability to form stable and transparent delivery systems with high oral bioavailability.In this study, the influence of system composition and preparation conditions on the particle size and sta-bility of vitamin D nanoemulsions prepared by spontaneous emulsification (SE) was investigated. SErelies on the formation of small oil droplets when an oil/surfactant mixture is titra...
106 Citations Source Cite
Published on Jan 1, 2015in Journal of Surfactants and Detergents 1.45
Patrycja Szumała5
Estimated H-index: 5
(Gdańsk University of Technology)
The influence of polyols as cosurfactants (propylene glycol PG; glycerol G) and short chain alcohol as a cosolvent (ethanol EtOH) on the formation and solubilization capacity of the systems: hexadecane/monoacylglycerols (MAG)/polyol/water:EtOH, at 60 °C, was investigated. Electrical conductivity measurement, and the DSC method were applied to determine the structure and type of microemulsions formed. The dimension of the droplets was characterized by DLS. It has been stated that concentration of...
12 Citations Source Cite
Published on Jan 1, 2015in Journal of Pharmaceutical Sciences 3.08
Hyo-Young Lee3
Estimated H-index: 3
(Pusan National University),
Young-Il Jeong32
Estimated H-index: 32
(Pusan National University)
+ 5 AuthorsKi-Choon Choi4
Estimated H-index: 4
(Rural Development Administration)
ABSTRACT: The aim of this study is to fabricate caffeic acid phenethyl ester (CAPE)-incorporated nanoparticles using methoxy poly(ethylene glycol)- b -poly(e-caprolactone) (CE) copolymer and to study their antitumor activity against pulmonary metastasis model of CT26 colon carcinoma cells. CAPE-incorporated nanoparticles showed spherical shapes having small diameters less than 300 nm and CAPE was continuously released from CE nanoparticles over 4 days. CAPE-incorporated polymeric micelles proper...
10 Citations Source Cite
Published on Jan 1, 2015in Journal of Nanomaterials 2.21
Serap Derman5
Estimated H-index: 5
(Yıldız Technical University)
CAPE loaded PLGA nanoparticles were prepared using the oil in water (o/w) single emulsion solvent evaporation methods. Five different processing parameters including initial CAPE amount, initial PLGA amount, PVA concentration in aqueous phase, PVA volume, and solvent type were screened systematically to improve encapsulation of hydrophobic CAPE molecule, simultaneously minimize particle size, and raise the reaction yield. Obtained results showed that the encapsulation efficiency of the nanoparti...
8 Citations Source Cite
Published on Oct 13, 2014in Molecules 3.10
Peng-Xuan Zhang2
Estimated H-index: 2
(Nanjing University),
Yu-Ping Tang7
Estimated H-index: 7
(Nanjing University)
+ 2 AuthorsJin-Ao Duan3
Estimated H-index: 3
(Nanjing University)
Caffeic acid phenethyl ester (CAPE), as one of the main active ingredients of the natural product propolis, shows the unique biological activities such as anti-tumor, anti-oxidation, anti-inflammatory, immune regulation, and so on. These have attracted the attention of many researchers to explore the compound with potent biological activities. This review aims to summarize its bioactivities, synthetic methods and derivatives, which will be helpful for further study and development of CAPE and it...
23 Citations Source Cite
Published on Oct 8, 2014in Journal of Agricultural and Food Chemistry 3.41
Jia Xue4
Estimated H-index: 4
,
Qixin Zhong31
Estimated H-index: 31
Many nanoemulsions are currently formulated with synthetic surfactants. The objective of the present work was to study the possibility of blending sodium caseinate (NaCas) and lecithin to prepare transparent thyme oil nanoemulsions. Thyme oil was emulsified using NaCas and soy lecithin individually or in combination at neutral pH by shear homogenization. The surfactant combination improved the oil content in transparent/translucent nanoemulsions, from 1.0% to 2.5% w/v for 5% NaCas with and witho...
40 Citations Source Cite
Published on Jul 8, 2014in Soft Matter 3.71
Kang Pan10
Estimated H-index: 10
(University of Tennessee),
Yangchao Luo28
Estimated H-index: 28
(University of Tennessee)
+ 2 AuthorsQixin Zhong31
Estimated H-index: 31
(University of Tennessee)
The poor water solubility and bioactivity of lipophilic phytochemicals can be potentially improved by delivery systems. In this study, a low-cost, low-energy, and organic solvent-free encapsulation technology was studied by utilizing the pH-dependent solubility properties of curcumin and self-assembly properties of sodium caseinate (NaCas). Curcumin was deprotonated and dissolved, while NaCas was dissociated at pH 12 and 21 °C for 30 min. The subsequent neutralization enabled the encapsulation o...
80 Citations Source Cite
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