The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction
Abstract
Eukaryotic ATP-dependent phosphofructokinases (PFKs) are often considered unidirectional enzymes catalysing the transfer of a phospho moiety from ATP to fructose 6-phosphate to produce ADP and fructose 1,6-bisphosphate. The reverse reaction is not generally considered to occur under normal conditions and has never been demonstrated for any eukaryotic ATP-dependent PFKs, though it does occur in inorganic pyrophosphate-dependent PFKs and has been...
Paper Details
Title
The kinetic characteristics of human and trypanosomatid phosphofructokinases for the reverse reaction
Published Date
Jan 18, 2019
Journal
Volume
476
Issue
2
Pages
179 - 191
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