Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction
Abstract
The CRISPR-Cas9 system is attractive for gene therapy, as it allows for permanent genetic correction. However, as a new technology, Cas9 gene editing in clinical applications faces major challenges, such as safe delivery and gene targeting efficiency. Cas9 is a foreign protein to recipient cells; thus, its expression may prompt the immune system to eliminate gene-edited cells. To overcome these challenges, we have engineered a novel delivery...
Paper Details
Title
Overcoming the Undesirable CRISPR-Cas9 Expression in Gene Correction
Published Date
Dec 1, 2018
Volume
13
Pages
699 - 709
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