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Molecular therapy. Nucleic acids
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5.92
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1055
Papers 1182
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#1Zhenghui Tang (Fudan University)
#2Tianyuan Xu (Fudan University)
Last.Yang Hong (Fudan University)H-Index: 3
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Abstract Accumulating evidence indicates that cryptochrome circadian regulatory (CRY) proteins have emerged as crucial regulators of osteogenic differentiation. However, the associated mechanisms are quite elusive. In this study, we show that knockdown of CRY2 down-regulated the expression of Runx2, ALP, OCN, and OPN to facilitate osteoblast differentiation. Further study identified that CRY2 was directly targeted by miR-7-5p that was highly induced during osteoblast differentiation. The express...
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#1Hui YongH-Index: 1
#2Gang-Ming Wu (CQMU: Chongqing Medical University)H-Index: 3
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Sepsis is a serious and elusive syndrome caused by infection, which is accompanied by a high mortality worldwide. Recent evidence has documented the regulatory role of long non-coding RNA (lncRNA) metastasis-associated lung adenocarcinoma transcript 1 (MALAT1) during the inflammatory process, the effects of which in the development of sepsis have become the focus of the current study. An in vivo mouse model and in vitro cell model of sepsis induced by lipopolysaccharide (LPS) were developed. Hig...
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#1Zhen-Hao Guo (CAS: Chinese Academy of Sciences)H-Index: 1
#2Zhu-Hong You (CAS: Chinese Academy of Sciences)H-Index: 31
Last.Hai-Cheng Yi (CAS: Chinese Academy of Sciences)H-Index: 5
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Abstract Detecting whether a pair of biomolecules associate is of great significance for the study of molecular biology. Hence, computational methods are urgently needed as guidance for practice. However, most of the previous prediction models influenced by reductionism focused on isolated research objects, which have their own inherent defects. Inspired by holism, a machine-learning based framework called MAN-Node2vec is proposed to predict multi-type relationships in Molecular Associations Net...
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#1Ling Ji (WMU: Wenzhou Medical College)
#2Xiang Li (WMU: Wenzhou Medical College)H-Index: 1
Last.Feizhao Jiang (WMU: Wenzhou Medical College)
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Abstract Long non-coding RNAs (lncRNAs) are crucial molecules in tumorigenesis and tumor growth in various human cancers, including colorectal cancer (CRC). Studies have revealed that lncRNAs can regulate cellular processes in cancers by interacting with proteins, for example RNA binding proteins (RBPs). Herein, we recognized a novel lncRNA called LINC01413 which is up-regulated in CRC tissues through lncRNAs microarray. Subsequently, it is confirmed that elevated level of LINC01413 expression i...
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#1Yanlan Yu (ZJU: Zhejiang University)
#2Fengbin Gao (ZJU: Zhejiang University)
Last.Guoqing Ding (ZJU: Zhejiang University)
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Abstract UCA1 (urothelial carcinoma associated 1) is a long non-coding RNA (lncRNA) which was found overexpressed in various human cancers including prostate cancer (PCa). However, the aspect of UCA1-miRNA-mRNA interaction in PCa remains unclear. In this study, we confirmed the role of UCA1 in PCa and found that UCA1 down-regulation inhibited cell proliferation of PCa cells. Then we demonstrated that repressed UCA1 promoted the miR-143 expression and miR-143 could bind to the predicted binding s...
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#1Nana Yan (NWAFU: Northwest A&F University)H-Index: 3
#2Yongsen Sun (NWAFU: Northwest A&F University)
Last.Zhiying Zhang (NWAFU: Northwest A&F University)H-Index: 1
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CRISPR/Cas9-mediated homology-directed repair (HDR) can be leveraged to precisely engineer mammalian genomes. However, the inherently low efficiency of HDR often hampers to identify the desired modified cells. Here, we developed a novel Universal Surrogate Reporter system that efficiently enriches for genetically modified cells arising from CRISPR/Cas9-induced HDR events (namely, HDR-USR). This episomally based reporter can be self-cleaved and self-repaired via HDR to create a functional puromyc...
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#1Xiaomin Liu (SHU: Shanghai University)H-Index: 1
#2Yang Shao (SHU: Shanghai University)
Last.Zhongliang Ma (SHU: Shanghai University)H-Index: 9
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Abstract Nuclear factor kappa B (NF-κB) acts as a nuclear factor which is composed of 5 main subunits. It is a pluripotent and crucial dimer transcription factor that has close relationship with many serious illnesses, especially influences cell proliferation, inflammation, cancer initiation and progression. NF-κB acts as part of the signaling pathway and determines its effect on the expression of several other genes, such as EGFR, p53, STAT3 and non-coding RNA. Continuous activation of NF-κB si...
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#1Natalia Papargyri (DTU: Technical University of Denmark)H-Index: 1
#2Malene Pontoppidan (DTU: Technical University of Denmark)H-Index: 1
Last.Peter H. Hagedorn (Hoffmann-La Roche)H-Index: 18
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Abstract The identification of molecules that can modulate RNA or protein function, and the subsequent chemical and structural optimization to refine such molecules into drugs, is a key activity in drug discovery. Here we explored the extent to which chemical and structural differences in antisense oligonucleotides, designed as gapmers and capable of recruiting RNase H for target RNA cleavage, can affect their functional properties. To facilitate structure-activity learning, we analyzed two sets...
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#1Elena M. Smekalova (MIT: Massachusetts Institute of Technology)H-Index: 6
#2Maxim V. Gerashchenko (Brigham and Women's Hospital)H-Index: 12
Last.Victor Kotelianski (Skolkovo Institute of Science and Technology)H-Index: 12
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Abstract Translation is an essential biological process and dysregulation is associated with a range of diseases including ribosomopathies, diabetes, and cancer. Here we examine translation dysregulation in vivo using RNA interference to knockdown the m-subunit of the translation initiation factor eIF3 in the mouse liver. Transcriptome sequencing, ribosome profiling, whole proteome, and phosphoproteome analyses show that eIF3m deficiency lead to the transcriptional response and changes in cellul...
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#1Xue-Jiao Chen (WMU: Wenzhou Medical College)H-Index: 3
#2Zi-Cheng Zhang (WMU: Wenzhou Medical College)H-Index: 1
Last.Zi-Bing Jin (WMU: Wenzhou Medical College)H-Index: 19
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Abstract Circular RNAs (circRNAs) represent a class of noncoding RNAs with a wide expression pattern, and they constitute an important layer of the genome regulatory network. To date, the expression pattern and regulatory potency of circRNAs in the retina, a key part of the central nervous system, are not yet well understood. In this study, RNAs from five stages (E18.5, P1, P7, P14 and P30) of mouse retinal development were sequenced. A total of 9029 circRNAs were identified. Most circRNAs were ...
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Top fields of study
Gene silencing
microRNA
Molecular biology
Cancer research
Biology
Cell biology