Match!

Indocyanine green for the prevention of anastomotic leaks following esophagectomy: a meta-analysis.

Published on Feb 1, 2019in Surgical Endoscopy and Other Interventional Techniques3.209
· DOI :10.1007/S00464-018-6503-7
Farah Ladak1
Estimated H-index: 1
(Brown University),
Farah Ladak3
Estimated H-index: 3
(Brown University)
+ 5 AuthorsShahzeer Karmali33
Estimated H-index: 33
(U of A: University of Alberta)
Sources
Abstract
Background Intraoperative evaluation with fluorescence angiography using indocyanine green (ICG) offers a dynamic assessment of gastric conduit perfusion and can guide anastomotic site selection during an esophagectomy. This study aims to evaluate the predictive value of ICG for the prevention of anastomotic leak following esophagectomy.
  • References (49)
  • Citations (17)
📖 Papers frequently viewed together
96 Citations
86 Citations
85 Citations
78% of Scinapse members use related papers. After signing in, all features are FREE.
References49
Newest
#1Simon R. Turner (U of A: University of Alberta)H-Index: 6
#2Daniela MolenaH-Index: 25
Last. Daniela R. Molena (MSK: Memorial Sloan Kettering Cancer Center)H-Index: 1
view all 2 authors...
: Intraoperative fluorescence imaging (FI) with indocyanine green has several potential uses during esophagectomy. Intravascular injection for enhancing the visualization of conduit vascularity and assessing macro and microperfusion has the most literature support and may help reduce anastomotic leaks. Peritumoral injection has been reported for use in identifying sentinel nodes during lymphadenectomy and intralymphatic injection may be used to help preserve or ligate the thoracic duct. The auth...
3 CitationsSource
Background Postoperative anastomotic leakage is a severe complication after gastric tube reconstruction during esophagectomy. The aim of this study was to evaluate the usefulness of postoperative endoscopic assessment of anastomosis and its correlation with intraoperative indocyanine green (ICG) fluorescence assessment of the gastric tube.
17 CitationsSource
2 CitationsSource
#1SchlottmannFrancisco (UNC: University of North Carolina at Chapel Hill)H-Index: 2
#2G PattiMarco (UNC: University of North Carolina at Chapel Hill)H-Index: 4
Last. G PattiMarcoH-Index: 1
view all 2 authors...
Abstract Background: Anastomotic leakage is a determining factor of morbidity and mortality after an esophagectomy. An adequate blood supply of the gastric conduit is vital to prevent this complication. We aimed to determine the feasibility and usefulness of indocyanine green (ICG) fluorescence imaging to evaluate the gastric conduit perfusion during an esophagectomy. Methods: Patients with distal esophageal cancer or esophagogastric junction cancer scheduled for esophagectomy were enrolled in t...
8 CitationsSource
#1Ioannis Karampinis (Heidelberg University)H-Index: 5
#2Ulrich Ronellenfitsch (Heidelberg University)H-Index: 20
Last. Kai Nowak (Heidelberg University)H-Index: 11
view all 8 authors...
Abstract Purpose Optimal perfusion of the gastric conduit during esophagectomy is elementary for the anastomotic healing since poor perfusion has been associated with increased morbidity due to anastomotic leaks. Until recently surgical experience was the main tool to assess the perfusion of the anastomosis. We hypothesized that anastomoses located in the zone of optimal ICG perfusion of the gastric conduit ("optizone") have a reduced anastomotic leakage rate after esophagectomy. Methods Indocya...
14 CitationsSource
#1Brian G.A. Dalton (University of Florida Health)H-Index: 1
#2Abubaker A. Ali (University of Florida Health)H-Index: 1
Last. Ziad T. Awad (University of Florida Health)H-Index: 1
view all 4 authors...
Abstract Introduction Anastomotic leak and conduit necrosis are devastating complications following Ivor Lewis esophagectomy. Near infrared imaging (NIR) using IndoCyanine Green allows for real time tissue perfusion assessment which may reduce anastomotic leak during minimally invasive Ivor Lewis esophagectomy (MIE). Methods Forty consecutive MIE were performed by a single surgeon at a tertiary referral center. The first 20 were assessed for gastric conduit perfusion by clinical criteria (Group ...
3 CitationsSource
#1Frans van WorkumH-Index: 8
Last. Camiel RosmanH-Index: 30
view all 16 authors...
Objective:To investigate the morbidity that is associated with the learning curve of minimally invasive esophagectomy.Background:Although learning curves have been described, it is currently unknown how much extra morbidity is associated with the learning curve of technically challenging surgical pr
46 CitationsSource
#1Masaki Ohi (Mie University)H-Index: 17
#2Yuji Toiyama (Mie University)H-Index: 36
Last. Masato Kusunoki (Mie University)H-Index: 41
view all 13 authors...
Backgrounds and aim Anastomotic leak (AL) following esophagectomy for esophageal cancer (EC) remains an important cause of prolonged hospitalization and impaired quality of life. Recently, indocyanine green (ICG) fluorescein imaging has been used to evaluate the gastric conduit blood supply during EC surgery. Although several factors have been reported to be associated with AL, no studies have evaluated the relationships between risk factors for AL, including ICG fluorescein imaging. The purpose...
23 CitationsSource
#1Carrie Ryan (USF: University of South Florida)H-Index: 3
#2Alessandro Paniccia (CU: University of Colorado Boulder)H-Index: 12
Last. Martin D. McCarter (CU: University of Colorado Boulder)H-Index: 43
view all 4 authors...
Introduction Leaks from intrathoracic esophagogastric anastomosis are thought to be associated with higher rates of morbidity and mortality than leaks from cervical anastomosis. We challenge this assumption and hypothesize that there is no significant difference in mortality based on the location of the esophagogastric anastomosis.
17 CitationsSource
#1Kazuhiro Noma (Okayama University)H-Index: 13
#2Yasuhiro Shirakawa (Okayama University)H-Index: 22
Last. Toshiyoshi Fujiwara (Okayama University)H-Index: 46
view all 9 authors...
Background Evaluation of the blood supply to gastric conduits is critically important to avoid complications after esophagectomy. We began visual evaluation of blood flow using indocyanine green (ICG) fluorescent imaging in July 2015, to reduce reconstructive complications. In this study, we aimed to statistically verify the efficacy of blood flow evaluation using our simplified ICG method. Study Design A total of 285 consecutive patients who underwent esophagectomy and gastric conduit reconstru...
12 CitationsSource
Cited By17
Newest
#1Akihiko Okamura (JFCR: Japanese Foundation for Cancer Research)H-Index: 7
#2Masayuki Watanabe (JFCR: Japanese Foundation for Cancer Research)H-Index: 41
Last. Hiroki Mitani (JFCR: Japanese Foundation for Cancer Research)H-Index: 8
view all 3 authors...
Source
#1Akihiko Okamura (JFCR: Japanese Foundation for Cancer Research)H-Index: 7
#2Masayuki Watanabe (JFCR: Japanese Foundation for Cancer Research)H-Index: 41
Last. Toru Sasaki (JFCR: Japanese Foundation for Cancer Research)H-Index: 2
view all 13 authors...
Pharyngolaryngectomy with total esophagectomy (PLTE) is often indicated for patients with synchronous head and neck cancer and thoracic esophageal cancer or those with head and neck cancer extending to the upper mediastinum. A long conduit is required for the reconstruction, and the blood flow at the tip of the conduit is not always sufficient. Thus, reconstructive surgery after PLTE remains challenging, and optimal reconstruction methods have not been elucidated to date. This analysis investiga...
1 CitationsSource
#1M FabbiH-Index: 1
#2E R C Hagens (UvA: University of Amsterdam)H-Index: 4
Last. S S Gisbertz (UvA: University of Amsterdam)H-Index: 3
view all 4 authors...
Anastomotic leakage is one of the most severe complications after esophagectomy and is associated with increased postoperative morbidity and mortality. Several projects ranging from small retrospective studies to large collaborations have aimed to identify potential pre- and perioperative risk factors and to improve the diagnostic processes and management. Despite the increase in available literature, many aspects of anastomotic leakage are still debated, without the existence of widely accepted...
1 CitationsSource
#1Hiroyuki KitagawaH-Index: 14
#2Tsutomu NamikawaH-Index: 19
Last. Kazuhiro HanazakiH-Index: 34
view all 7 authors...
PURPOSE: To evaluate the correlation between blood supply speed in the gastric tube (GT), assessed by the intraoperative indocyanine green (ICG) fluorescence method, and postoperative endoscopic assessment (PEA) of the anastomosis or anastomotic leakage (AL). METHODS: The subjects of this retrospective analysis were 66 consecutive patients who underwent GT reconstruction using ICG fluorescence during esophageal surgery. We measured the ICG visualization time, from ICG injection to visualization ...
Source
Source
Resumen La esofagectomia es el principal tratamiento con fines curativos de los canceres del esofago. Suele realizarse en el marco de un tratamiento multimodal que integra un tratamiento preoperatorio con radioquimioterapia o quimioterapia. Las esofagectomias son intervenciones laboriosas y complejas, que solo se pueden plantear en centros equipados y dotados de una unidad de reanimacion postoperatoria. Solo pueden proponerse con fines curativos, despues de una evaluacion preoperatoria que permi...
Source
Riassunto L’esofagectomia resta il principale trattamento a scopo curativo dei cancri dell’esofago. E spesso realizzata nell’ambito di una gestione multimodale che integra un trattamento preoperatorio mediante radiochemioterapia o chemioterapia. Le esofagectomie sono interventi pesanti e complessi, che possono essere presi in considerazione solo in centri attrezzati e dotati di una rianimazione postoperatoria. Possono essere proposte solo a scopo curativo, al termine di un bilancio preoperatorio...
Source
#1Marcel Hochreiter (University Hospital Heidelberg)H-Index: 9
#2Thomas Schmidt (University Hospital Heidelberg)H-Index: 26
Last. Markus W. Büchler (University Hospital Heidelberg)H-Index: 87
view all 11 authors...
Atrial fibrillation (AF) represents the most frequent arrhythmic disorder after thoracoabdominal esophageal resection and is associated with a significant increase in perioperative morbidity and mortality. In this retrospective cohort study, 167 patients who underwent thoracoabdominal esophagectomy at a large university hospital were assessed. We compared patients who received a 14-day postoperative course of diltiazem with a control group of patients who did not undergo diltiazem prophylaxis. D...
1 CitationsSource
#1Nima Khavanin (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 2
#2Hamda Almaazmi (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 1
Last. Justin M. Sacks (JHUSOM: Johns Hopkins University School of Medicine)H-Index: 19
view all 6 authors...
BACKGROUND: This study aims to directly compare measurements of tissue oxygenation obtained using the Intra.Ox (Vioptix Inc., Fremont, CA) near infrared spectrometer with the perfusion assessment of the indocyanine green (ICG)-based SPY Elite imaging system (Stryker Co., Kalamazoo, MI) in a porcine bowel model. METHODS: Two live minipigs underwent laparotomy and isolation of a 30-cm segment of a large bowel. Standardized oximetry measurements were taken along the segment of bowel immediately bef...
Source
#1Hiroshi IdogawaH-Index: 1
#2Tomohiro SakashitaH-Index: 15
Last. Akihiro Homma (Hokkaido University)H-Index: 21
view all 3 authors...
Recently it was reported that the parathyroid glands (PGs) emit autofluorescence when exposed to near infrared light, and a technique using fluorescence to detect the PGs intraoperatively was found to be useful. In some cases, however, it was difficult to detect the PGs. We sought to clarify the situation regarding such undetectable cases. The study comprised 45 patients (50 sides) who underwent thyroid or parathyroid surgery at Kushiro city general hospital between November 2018 and June 2019. ...
1 CitationsSource