Downregulation of Dopamine D1-like Receptor Pathways of GABAergic Interneurons in the Anterior Cingulate Cortex of Spontaneously Hypertensive Rats

Deficits in dopaminergic function are thought to underlie attention-deficit/hyperactivity disorder (ADHD). Dopaminergic neurons are the main source of dopamine (DA), a neurotransmitter that acts as a neuromodulator of cognitive function in the prefrontal cortex, including the anterior cingulate cortex (ACC), which receives dopaminergic inputs from the ventral tegmental area. The spontaneously hypertensive rat (SHR) has been widely studied as an...