Switch to low-fat diet improves outcome of acute lymphoblastic leukemia in obese mice

It is becoming increasingly recognized that weight and nutritional status can impact cancer survival. We have previously shown that obese mice with syngeneic acute lymphoblastic leukemia (ALL) have poorer response to chemotherapy treatment than control mice. We therefore investigated whether dietary intervention could improve outcome from the most common pediatric cancer, ALL. Diet-induced obese (DIO) mice raised on a 60% calories from fat diet...