Original paper
High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population
Abstract
The discovery of the highly efficient site-specific nuclease system CRISPR-Cas9 from Streptococcus pyogenes has galvanized the field of gene therapy1,2. The immunogenicity of Cas9 nuclease has been demonstrated in mice3,4. Preexisting immunity against therapeutic gene vectors or their cargo can decrease the efficacy of a potentially curative treatment and may pose significant safety issues3-6. S. pyogenes is a common cause for infectious...
Paper Details
Title
High prevalence of Streptococcus pyogenes Cas9-reactive T cells within the adult human population
Published Date
Oct 29, 2018
Journal
Volume
25
Issue
2
Pages
242 - 248
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Notes
History