Evolution of Metastases in Space and Time under Immune Selection
Abstract
We examined how the immune microenvironment molds tumor evolution at different metastatic organs in a longitudinal dataset of colorectal cancer. Through multiplexed analyses, we showed that clonal evolution patterns during metastatic progression depend on the immune contexture at the metastatic site. Genetic evidence of neoantigen depletion was observed in the sites with high Immunoscore and spatial proximity between Ki67+ tumor cells and CD3+...
Paper Details
Title
Evolution of Metastases in Space and Time under Immune Selection
Published Date
Oct 1, 2018
Journal
Volume
175
Issue
3
Pages
751 - 765.e16
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Notes
History