DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
Abstract
DNMT3L (DNMT3-like), a member of the DNMT3 family, has no DNA methyltransferase activity but regulates de novo DNA methylation. While biochemical studies show that DNMT3L is capable of interacting with both DNMT3A and DNMT3B and stimulating their enzymatic activities, genetic evidence suggests that DNMT3L is essential for DNMT3A-mediated de novo methylation in germ cells but is dispensable for de novo methylation during embryogenesis, which is...
Paper Details
Title
DNMT3L facilitates DNA methylation partly by maintaining DNMT3A stability in mouse embryonic stem cells
Published Date
Oct 13, 2018
Journal
Volume
47
Issue
1
Pages
152 - 167
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