EROS/CYBC1 mutations: Decreased NADPH oxidase function and chronic granulomatous disease

The multi-subunit phagocyte nicotinamide adenine dinucleotide phosphate oxidase generates reactive oxygen species and is crucial for host defence.1Segal A.W. How neutrophils kill microbes.Ann Rev Immunol. 2005; 23: 197-223Crossref PubMed Scopus (1286) Google Scholar Deficiencies in individual subunits (gp91phox, p22phox, p47phox, p67phox, and p40phox) cause chronic granulomatous disease (CGD), but some patients with CGD do not have mutations in...