Original paper
Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding
Volume: 293, Issue: 51, Pages: 19532 - 19543
Published: Dec 1, 2018
Abstract
Phenylalanine hydroxylase (PAH) regulates phenylalanine (Phe) levels in mammals to prevent neurotoxicity resulting from high Phe concentrations as observed in genetic disorders leading to hyperphenylalaninemia and phenylketonuria. PAH senses elevated Phe concentrations by transient allosteric Phe binding to a protein–protein interface between ACT domains of different subunits in a PAH tetramer. This interface is present in an activated PAH...
Paper Details
Title
Simulations of the regulatory ACT domain of human phenylalanine hydroxylase (PAH) unveil its mechanism of phenylalanine binding
Published Date
Dec 1, 2018
Volume
293
Issue
51
Pages
19532 - 19543
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Notes
History