Chemotherapy Curtails Bone Formation From Compliant Compression Fixation of Distal Femoral Endoprostheses

Background Modulated compliant compressive forces may contribute to durable fixation of implant stems in patients with cancer who undergo endoprosthetic reconstruction after tumor resection. Chemotherapy effects on bone hypertrophy and osteointegration have rarely been studied, and no accepted radiologic method exists to evaluate compression-associated hypertrophy. Questions/purposes (1) What was the effect of chemotherapy on the newly formed...