Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant
Abstract
Single-particle cryogenic electron microscopy (cryo-EM) provides a powerful methodology for structural biologists, but the resolutions typically attained with experimentally determined structures have lagged behind microscope capabilities. Here, we exploit several technical advances to improve resolution, including per-particle contrast transfer function (CTF) refinement and correction for Ewald sphere curvature. The latter is demonstrated with...
Paper Details
Title
Sub-2 Å Ewald curvature corrected structure of an AAV2 capsid variant
Published Date
Sep 7, 2018
Journal
Volume
9
Issue
1
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