Original paper

Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion

Volume: 551, Issue: 1-2, Pages: 241 - 256
Published: Nov 1, 2018
Abstract
The comparison of spray drying versus hot melt extrusion (HME) in order to formulate amorphous solid dispersions has been widely studied. However, to the best of our knowledge, the use of both techniques to form cocrystals within a carrier excipient has not previously been compared. The combination of ibuprofen (IBU) and isonicotinamide (INA) in a 1:1 M ratio was used as a model cocrystal. A range of pharmaceutical excipients was selected for...
Paper Details
Title
Engineering of pharmaceutical cocrystals in an excipient matrix: Spray drying versus hot melt extrusion
Published Date
Nov 1, 2018
Volume
551
Issue
1-2
Pages
241 - 256
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