A protocol for precise comparisons of small vessel disease lesions between ex vivo magnetic resonance imaging and histopathology

Rationale Neuroimaging and clinical studies have defined human sporadic cerebral small vessel disease but the pathophysiology remains relatively poorly understood. To develop effective therapies and preventative strategies, we must better understand the heterogeneity and development of small vessel disease at a cellular level. Hypothesis Small vessel disease lesions as seen on neuroimaging have specific neuropathological correlates. Methods and...