Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
Abstract
Here, we report DNA methylation and hydroxymethylation dynamics at nucleotide resolution using C/EBPα-enhanced reprogramming of B cells into induced pluripotent cells (iPSCs). We observed successive waves of hydroxymethylation at enhancers, concomitant with a decrease in DNA methylation, suggesting active demethylation. Consistent with this finding, ablation of the DNA demethylase Tet2 almost completely abolishes reprogramming. C/EBPα, Klf4, and...
Paper Details
Title
Transcription Factors Drive Tet2-Mediated Enhancer Demethylation to Reprogram Cell Fate
Published Date
Nov 1, 2018
Journal
Volume
23
Issue
5
Pages
727 - 741.e9
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