Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories
Abstract
Expression of vast repertoires of antigen receptors by lymphocytes, with each cell expressing a single receptor, requires stochastic activation of individual variable (V) genes for transcription and recombination. How this occurs remains unknown. Using single-cell RNA sequencing (scRNA-seq) and allelic variation, we show that individual pre-B cells monoallelically transcribe divergent arrays of Vκ genes, thereby opening stochastic repertoires...
Paper Details
Title
Regulated Capture of Vκ Gene Topologically Associating Domains by Transcription Factories
Published Date
Aug 1, 2018
Journal
Volume
24
Issue
9
Pages
2443 - 2456
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