Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
Abstract
T cells represent a critical effector of cell-mediated immunity. Activated T cells engage in metabolic reprogramming during effector differentiation to accommodate dynamic changes in energy demands. Here, we show that the hormone, insulin, and downstream signaling through its insulin receptor shape adaptive immune function through modulating T cell metabolism. T cells lacking insulin receptor expression (LckCre+ Insrfl/fl) show reduced...
Paper Details
Title
Insulin Receptor-Mediated Stimulation Boosts T Cell Immunity during Inflammation and Infection
Published Date
Dec 1, 2018
Journal
Volume
28
Issue
6
Pages
922 - 934.e4
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