Pharmacological inhibition of histone deacetylase mitigates markers of oxidative stress and inflammation in hypercholesterolemic apolipoprotein E deficient mice

Aim: Acetylation of histone and non-histone proteins, controlled by histone acetyltransferases and histone deacetylases (HDAC), play a major role in regulation of gene expression. Evidence exists that HDAC inhibitors display beneficial effects in several experimental models of cardiovascular diseases. The role of HDAC isoforms in atherogenesis is not completely understood. The aim of this study was to investigate the expression profile of...