CRISPR-C: circularization of genes and chromosome by CRISPR in human cells
Abstract
Extrachromosomal circular DNA (eccDNA) and ring chromosomes are genetic alterations found in humans with genetic disorders. However, there is a lack of genetic engineering tools to recapitulate and study the biogenesis of eccDNAs. Here, we created a dual-fluorescence biosensor cassette, which upon the delivery of pairs of CRISPR/Cas9 guide RNAs, CRISPR-C, allows us to study the biogenesis of a specific fluorophore expressing eccDNA in human...
Paper Details
Title
CRISPR-C: circularization of genes and chromosome by CRISPR in human cells
Published Date
Aug 24, 2018
Journal
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History