Original paper
Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion
Abstract
Base editors (BEs) enable the generation of targeted single-nucleotide mutations, but currently used rat APOBEC1-based BEs are relatively inefficient in editing cytosines in highly methylated regions or in GpC contexts. By screening a variety of APOBEC and AID deaminases, we show that human APOBEC3A-conjugated BEs and versions we engineered to have narrower editing windows can mediate efficient C-to-T base editing in regions with high...
Paper Details
Title
Efficient base editing in methylated regions with a human APOBEC3A-Cas9 fusion
Published Date
Aug 20, 2018
Journal
Volume
36
Issue
10
Pages
946 - 949
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Notes
History