Maternally-derived Antibodies to Schizont Egress Antigen-1 and Protection of Infants From Severe Malaria

In holoendemic areas, children suffer the most from Plasmodium falciparum malaria, yet newborns and young infants express a relative resistance to both infection and severe malarial disease (SM). This relative resistance has been ascribed to maternally-derived anti-parasite immunoglobulin G; however, the targets of these protective antibodies remain elusive.We enrolled 647 newborns at birth from a malaria-holoendemic region of Tanzania. We...