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Clinical Infectious Diseases
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#1Isabelle Vock (University of Basel)H-Index: 1
#2Lisandra Aguilar-Bultet (University of Basel)H-Index: 1
Last. Sarah Tschudin-Sutter (University of Basel)H-Index: 19
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We investigated relative proportions of extended-spectrum beta-lactamase-producing Enterobacterales (ESBL-PE) versus non-ESBL-PE (nESBL-PE) infections in ESBL-PE colonized patients. ESBL-PE are not causative for the majority of infections in hospitalized patients colonized with ESBL-PE. Site of infection and patient-level exposures may be useful predictors of nESBL-PE infections, potentially guiding empiric treatment recommendations.
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#1Leigh M. Howard (VUMC: Vanderbilt University Medical Center)H-Index: 7
#2Kathryn M. Edwards (VUMC: Vanderbilt University Medical Center)H-Index: 89
Last. Jonathan A. McCullers (UT: University of Tennessee)H-Index: 44
view all 13 authors...
BACKGROUND Parainfluenza virus (PIV) is a leading cause of lower respiratory tract infections. Although there are several distinct PIV serotypes, few studies have compared the clinical characteristics and severity of infection among the individual PIV serotypes and between PIV and other pathogens in patients with community-acquired pneumonia. METHODS We conducted active population-based surveillance for radiographically confirmed community-acquired pneumonia hospitalizations among children and a...
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#1Rohma Ghani (Imperial College London)H-Index: 1
#2Benjamin H. Mullish (Imperial College London)H-Index: 12
Last. Neill Duncan (Imperial College Healthcare)H-Index: 15
view all 16 authors...
Fecal microbiota transplantation (FMT) yields variable intestinal decolonization results for multidrug-resistant organisms (MDROs). This study showed significant reductions in antibiotic duration, bacteremia and length of stay in 20 patients colonized/ infected with MDRO receiving FMT (compared to pre-FMT history, and a matched group not receiving FMT), despite modest decolonization rates.
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#1Jay N Worley (Brigham and Women's Hospital)H-Index: 1
#2Mary L. Delaney (Brigham and Women's Hospital)H-Index: 24
Last. Lynn Bry (Brigham and Women's Hospital)H-Index: 33
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BACKGROUND Clostridioides difficile infections (CDIs) are among the most prevalent hospital-associated infections (HAIs), particularly for intensive care unit (ICU) patients. The risks for developing active CDI from asymptomatic carriage of C. difficile are not well understood. METHODS We identified asymptomatic C. difficile carriage among 1897 ICU patients, using rectal swabs from an existing ICU vancomycin-resistant Enterococci (VRE) surveillance program. C. difficile isolates from VRE swabs, ...
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#1Stanley A. Plotkin (UPenn: University of Pennsylvania)H-Index: 60
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BACKGROUND: No therapeutics have yet been proven effective for the treatment of mild-illness caused by SARS-CoV-2. We aimed to determine whether early treatment with hydroxychloroquine (HCQ) would be more efficacious than no-treatment for outpatients with mild Covid-19. METHODS: We conducted a multicenter, open label, randomized controlled trial in Catalonia (Spain) between March 17, and May 26, 2020. Eligible Covid-19 cases were non-hospitalized adult patients with recently confirmed SARS-CoV-2...
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#1Claudia Alteri (University of Milan)H-Index: 16
#2Valeria Cento (University of Milan)H-Index: 17
Last. Carlo Federico Perno (University of Milan)H-Index: 55
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#1Vincent Dupont (URCA: University of Reims Champagne-Ardenne)H-Index: 2
Last. Bruno MourvillierH-Index: 30
view all 11 authors...
Excess soluble fms-like tyrosine kinase 1 (sFlt-1), a soluble inhibitor of the vascular endothelial growth factor pathway, has been demonstrated to promote endothelial dysfunction. Here we demonstrate that sFlt-1 plasma levels correlate with respiratory symptoms severity, expression of endothelial dysfunction biomarker and incidence of organ failure in COVID-19 patients.
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Top fields of study
Virology
Intensive care medicine
Immunology
Immunodeficiency
Population
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Microbiology