Original paper
Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
Abstract
RNA sequencing (RNA-seq) detects estrogen receptor alpha gene (ESR1) fusion transcripts in estrogen receptor-positive (ER+) breast cancer, but their role in disease pathogenesis remains unclear. We examined multiple ESR1 fusions and found that two, both identified in advanced endocrine treatment-resistant disease, encoded stable and functional fusion proteins. In both examples, ESR1-e6>YAP1 and ESR1-e6>PCDH11X, ESR1 exons 1–6 were fused in frame...
Paper Details
Title
Functional Annotation of ESR1 Gene Fusions in Estrogen Receptor-Positive Breast Cancer
Published Date
Aug 1, 2018
Journal
Volume
24
Issue
6
Pages
1434 - 1444.e7
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Notes
History