Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Abstract
Streptococcus pneumoniae is a common nasopharyngeal colonizer, but can also cause life-threatening invasive diseases such as empyema, bacteremia and meningitis. Genetic variation of host and pathogen is known to play a role in invasive pneumococcal disease, though to what extent is unknown. In a genome-wide association study of human and pathogen we show that human variation explains almost half of variation in susceptibility to pneumococcal...
Paper Details
Title
Joint sequencing of human and pathogen genomes reveals the genetics of pneumococcal meningitis
Published Date
May 15, 2019
Journal
Volume
10
Issue
1
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