doi.org/10.1158/1538-7445.am2018-lb-360
Original paper

Abstract LB-360: JNKs-mediated phosphorylation of human stromal xbp1s regulates multiple myeloma growth & osteolysis

..., Hongjiao Ouyang
21
Cancer Research12.50
Volume: 78, Issue: 13_Supplement, Pages: LB - 360
Published: Jul 1, 2018
Abstract
Spliced X-box binding protein-1 (XBP1s) is a major effector of the unfolded protein response (UPR) signaling. We previously reported that human XBP1s in bone marrow stromal cells plays an essential role in regulating stromal support of multiple myeloma bone disease (MMBD). Here we report that human XBP1s (hXBP1s) is a physiological & direct phosphorylation substrate of JNKs. This phosphorylation greatly increases hXBP1s protein degradation...
Paper Fields
Paper Details
Title
Abstract LB-360: JNKs-mediated phosphorylation of human stromal xbp1s regulates multiple myeloma growth & osteolysis
DOI
doi.org/10.1158/1538-7445.am2018-lb-360
Published Date
Jul 1, 2018
Journal
Cancer Research
Volume
78
Issue
13_Supplement
Pages
LB - 360
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