Characterization of left ventricle function in chronic TNF-mediated experimental arthritis

Background: Patients with Rheumatoid Arthritis (RA) have an increased risk for cardiovascular disorders. RA is often associated with left ventricle (LV) systolic dysfunction, however the contribution of chronic inflammatory burden on cardiac functional impairment is not completely understood. Recently, LV systolic dysfunction in heart failure is associated with the down regulation and impairment of neuregulin-1 (NRG1)/Receptor Tyrosine Kinase 2...