Original paper

PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating

Volume: 92, Issue: 20
Published: Oct 15, 2018
Abstract
The capsid-binding small molecule PF74 inhibits HIV-1 infection at early stages and perturbs uncoating. However, the mechanism by which PF74 alters capsid stability and reduces viral infection is presently unknown. We recently introduced time-lapse atomic force microscopy to study the morphology and physical properties of HIV-1 cores during the course of reverse transcription. Here, we apply this AFM methodology to show that PF74 prevented the...
Paper Details
Title
PF74 Reinforces the HIV-1 Capsid To Impair Reverse Transcription-Induced Uncoating
Published Date
Oct 15, 2018
Volume
92
Issue
20
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