β-Catenin Regulation in Sporadic Colorectal Carcinogenesis: Not as Simple as APC

Background . The wnt/APC/ β -catenin pathway is a critical initiator in colorectal carcinogenesis in both hereditary and sporadic colorectal cancer (CRC). The progression of this process remains incompletely understood, although inflammation is pivotal. Drivers of inflammation are elevated in malignant tissue and have been shown to regulate β -catenin expression. Interleukin-17A (IL-17A) is protumorigenic at elevated levels via COX-2...