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Knockout of hyaluronan synthase 1, but not 3, impairs formation of the retrocalcaneal bursa

Published on Oct 1, 2018in Journal of Orthopaedic Research3.043
路 DOI :10.1002/jor.24027
Katie J. Sikes2
Estimated H-index: 2
,
Kristen Renner2
Estimated H-index: 2
+ 7 AuthorsVincent M. Wang26
Estimated H-index: 26
Abstract
  • References (58)
  • Citations (2)
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References58
Newest
#1Deva D. ChanH-Index: 12
#2Jun LiH-Index: 18
Last. Anna PlaasH-Index: 41
view all 6 authors...
Pirfenidone is an anti-inflammatory and anti-fibrotic drug that has shown efficacy in lung and kidney fibrosis. Because inflammation and fibrosis have been linked to the progression of osteoarthritis, we investigated the effects of oral Pirfenidone in a mouse model of cartilage injury, which results in chronic inflammation and joint-wide fibrosis in mice that lack hyaluronan synthase 1 (Has1鈭/鈭) in comparison to wild-type. Femoral cartilage was surgically injured in wild-type and Has1鈭/鈭 mice, a...
2 CitationsSource
#1Przemys艂aw A. P臋kala (Jagiellonian University Medical College)H-Index: 7
#2Brandon Michael Henry (Jagiellonian University Medical College)H-Index: 12
Last. Krzysztof A. Tomaszewski (Jagiellonian University Medical College)H-Index: 19
view all 5 authors...
ObjectivesInflammation of the retrocalcaneal bursa (RB) is a common clinical problem, particularly in professional athletes. RB inflammation is often treated with corticosteroid injections however a number of reports suggest an increased risk of Achilles tendon (AT) rupture. The aim of this cadaveric study was to describe the anatomical connections of the RB and to investigate whether it is possible for fluid to move from the RB into AT tissue.MethodsA total of 20 fresh-frozen AT specimens were ...
5 CitationsSource
#1Katie J. Trella (UIC: University of Illinois at Chicago)H-Index: 3
#2Jun Li (Rush University Medical Center)H-Index: 18
Last. Robert W. Wysocki (Rush University Medical Center)H-Index: 28
view all 9 authors...
We have used a murine Achilles tendinopathy model to investigate whether tissue changes (such as collagen disorganization, chondroid metaplasia, and loss of tensile properties) which are broadly characteristic of human tendinopathies, are accompanied by changes in the expression of chromatin-modifying enzymes and the methylation status of promoter regions of tendon cell DNA. Tendinopathy was induced by two intra-tendinous TGF-尾1 injections followed by cage activity or treadmill running for up to...
7 CitationsSource
#1Tiina A. Jokela (University of Eastern Finland)H-Index: 10
#2Riikka K盲rn盲 (University of Eastern Finland)H-Index: 13
Last. Raija Tammi (University of Eastern Finland)H-Index: 45
view all 8 authors...
5 CitationsSource
#1Satu TiainenH-Index: 3
#2Sanna Oikari (University of Eastern Finland)H-Index: 15
Last. P盲ivi AuvinenH-Index: 25
view all 8 authors...
Purpose Obesity and oversupply of glucose, e.g., due to nutritional factors may shape the tumor microenvironment favorable for tumor progression. O-GlcNAcylation, a reversible modification of intracellular proteins, influences on several cellular functions and is connected to many diseases including cancer. Glycosaminoglycan hyaluronan (HA) enhances tumor progression and in breast cancer HA accumulation associates strongly with poor outcome. In vitro studies have suggested that O-GlcNAcylation m...
8 CitationsSource
#1Guofeng Yang (Tongji University)H-Index: 1
#2Beizhan Jiang (Tongji University)H-Index: 4
Last. Shouliang Zhao (Fudan University)H-Index: 5
view all 5 authors...
Hyaluronan (HA) and hyaluronan synthases (HASs) have been shown to play critical roles in embryogenesis and organ development. However, there have not been any studies examining HA and HAS expression and localization during tooth development. The present study was designed to investigate the expression of HA and three isoforms of HASs (HAS1, 2, 3) in embryonic mouse molars. The first mandibular embryonic mouse molars were examined by immunohistochemistry at E11.5, E13.5, E14.5, E16.5, and E18.5....
6 CitationsSource
#1Deva D. Chan (Rush University Medical Center)H-Index: 12
#2W.F. Xiao (CSU: Central South University)H-Index: 1
Last. Anna Plaas (Rush University Medical Center)H-Index: 41
view all 6 authors...
Summary Objective Articular cartilage defects commonly result from traumatic injury and predispose to degenerative joint diseases. To test the hypothesis that aberrant healing responses and chronic inflammation lead to osteoarthritis (OA), we examined spatiotemporal changes in joint tissues after cartilage injury in murine knees. Since intra-articular injection of hyaluronan (HA) can attenuate injury-induced osteoarthritis in wild-type (WT) mice, we investigated a role for HA in the response to ...
15 CitationsSource
#1Ville Koistinen (University of Eastern Finland)H-Index: 5
#2Riikka K盲rn盲 (University of Eastern Finland)H-Index: 13
Last. Kirsi Rilla (University of Eastern Finland)H-Index: 26
view all 6 authors...
Abstract Previous studies have shown that overexpression of enzymatically active GFP-HAS induces the growth of long, slender protrusions that share many features of both filopodia and microvilli. These protrusions are dependent on continuing hyaluronan synthesis, and disrupt upon digestion of hyaluronan by hyaluronidase. However, complete understanding of their nature is still missing. This work shows that the protrusions on rat peritoneal surface are ultrastructurally indistinguishable from tho...
13 CitationsSource
#1Sean P. Kessler (Cleveland Clinic)H-Index: 15
#2Dana R. Obery (Cleveland Clinic)H-Index: 3
Last. Carol A. de la Motte (Cleveland Clinic)H-Index: 32
view all 3 authors...
Hyaluronan (HA) overproduction is a hallmark of multiple inflammatory diseases, including inflammatory bowel disease (IBD). Hyaluronan can act as a leukocyte recruitment molecule and in the most common mouse model of intestinal inflammation, the chemically induced dextran sodium sulfate (DSS) experimental colitis model, we previously determined that changes in colon distribution of HA occur before inflammation. Therefore, we hypothesized that, during a pathologic challenge, HA promotes inflammat...
20 CitationsSource
#1Mary K. Cowman (NYU: New York University)H-Index: 34
#2Tannin A. Schmidt (U of C: University of Calgary)H-Index: 26
Last. Antonio Stecco (UNIPD: University of Padua)H-Index: 17
view all 4 authors...
Hyaluronan (HA) is a high molecular weight glycosaminoglycan of the extracellular matrix (ECM), which is particularly abundant in soft connective tissues. Solutions of HA can be highly viscous with non-Newtonian flow properties. These properties affect the movement of HA-containing fluid layers within and underlying the deep fascia. Changes in the concentration, molecular weight, or even covalent modification of HA in inflammatory conditions, as well as changes in binding interactions with other...
49 CitationsSource
Cited By2
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#1Stavros Garantziotis (UTSW: University of Texas Southwestern Medical Center)H-Index: 30
#2Rashmin C. Savani (UTSW: University of Texas Southwestern Medical Center)H-Index: 1
Abstract Cell-matrix interactions are fundamental to many developmental, homeostatic, immune and pathologic processes. Hyaluronan (HA), a critical component of the extracellular matrix (ECM) that regulates normal structural integrity and development, also regulates tissue responses during injury, repair, and regeneration. Though simple in its primary structure, HA regulates biological responses in a highly complex manner with balanced contributions from its molecular size and concentration, synt...
6 CitationsSource