doi.org/10.12688/f1000research.15523.1
Original paper

PDZD8 is not the ‘functional ortholog’ of Mmm1, it is a paralog

..., Thomas A. Richards
44
F1000Research
Volume: 7, Pages: 1088 - 1088
Published: Jul 16, 2018
Abstract
Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a “functional ortholog” of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data...
Paper Fields
Paper Details
Title
PDZD8 is not the ‘functional ortholog’ of Mmm1, it is a paralog
DOI
doi.org/10.12688/f1000research.15523.1
Published Date
Jul 16, 2018
Journal
F1000Research
Volume
7
Pages
1088 - 1088
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