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Jeremy G. Wideman
University of Exeter
25Publications
11H-index
296Citations
Publications 25
Newest
2018
Guy Leonard1
Estimated H-index: 1
,
Aurélie Labarre1
Estimated H-index: 1
+ 14 AuthorsXavier Grau-Bové7
Estimated H-index: 7
Source Cite
2018 in Journal of Cell BiologyIF: 8.78
Sevan Mattie3
Estimated H-index: 3
(Montreal Neurological Institute and Hospital),
Jan Riemer25
Estimated H-index: 25
(University of Cologne)
+ 1 AuthorsHeidi M. McBride30
Estimated H-index: 30
(Montreal Neurological Institute and Hospital)
Mitochondrial fusion occurs in many eukaryotes, including animals, plants, and fungi. It is essential for cellular homeostasis, and yet the underlying mechanisms remain elusive. Comparative analyses and phylogenetic reconstructions revealed that fungal Fzo1 and animal Mitofusin proteins are highly diverged from one another and lack strong sequence similarity. Bioinformatic analysis showed that fungal Fzo1 proteins exhibit two predicted transmembrane domains, whereas metazoan Mitofusins contain o...
11 Citations Source Cite
2018 in Open BiologyIF: 3.29
Guy Leonard1
Estimated H-index: 1
(University of Exeter),
Aurélie Labarre1
Estimated H-index: 1
(University of Exeter)
+ 14 AuthorsXavier Grau-Bové7
Estimated H-index: 7
(Spanish National Research Council)
Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. The Fungi successfully coupled osmotrophy with filamentous growth, and similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing ...
1 Citations Source Cite
André Luiz Gomes-Vieira2
Estimated H-index: 2
(Universidade Federal Rural do Rio de Janeiro),
Jeremy G. Wideman11
Estimated H-index: 11
(University of Exeter)
+ 3 AuthorsJosé Roberto Meyer-Fernandes28
Estimated H-index: 28
(Federal University of Rio de Janeiro)
Abstract The model yeast Saccharomyces cerevisiae elicits a transcriptional response to phosphate (P i ) depletion. To determine the origins of the phosphate response (PHO) system, we bioinformatically identified putative PHO components in the predicted proteomes of diverse fungi. Our results suggest that the PHO system is ancient; however, components have been expanded or lost in different fungal lineages. To show that a similar physiological response is present in deeply-diverging fungi we exa...
2 Citations Source Cite
Jeremy G. Wideman11
Estimated H-index: 11
(University of Exeter),
Dario L. Balacco1
Estimated H-index: 1
(University of Nottingham)
+ 1 AuthorsThomas A. Richards35
Estimated H-index: 35
(University of Exeter)
Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a “functional ortholog” of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering....
Source Cite
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University),
Jeremy G. Wideman11
Estimated H-index: 11
(University of Exeter)
+ 1 AuthorsClaudio H. Slamovits26
Estimated H-index: 26
(Canadian Institute for Advanced Research)
9 Citations Source Cite
Alexander Eve (University of Exeter), Joshua Donnelly (University of Exeter)+ 3 AuthorsPhilip W. Ingham72
Estimated H-index: 72
(University of Exeter)
Source Cite
Thomas A. Richards35
Estimated H-index: 35
(University of Exeter),
Guy Leonard13
Estimated H-index: 13
(University of Exeter),
Jeremy G. Wideman11
Estimated H-index: 11
(University of Exeter)
It is a certainty that the tree of life can be broken up into large units of biodiversity that span such great evolutionary distances that one could call them kingdoms. However, if these units are to have any meaning, they must represent radiations of diverse groups underpinned by unique shared derived adaptations that drove the evolutionary success of each group. Without such evolutionary characters, these classifications are merely abstract concepts or arbitrarily demarcated lineages. Even the...
5 Citations Source Cite
Maureen A. O’Malley3
Estimated H-index: 3
(University of Bordeaux),
Jeremy G. Wideman11
Estimated H-index: 11
(University of Exeter),
Iñaki Ruiz-Trillo29
Estimated H-index: 29
(University of Barcelona)
Macroevolutionary patterns can be produced by combinations of diverse and even oppositional dynamics. A growing body of data indicates that secondary simplifications of molecular and cellular structures are common. Some major diversifications in eukaryotes have occurred because of loss and minimalisation; numerous episodes in prokaryote evolution have likewise been driven by the reduction of structure. After examining a range of examples of secondary simplification and its consequences across th...
15 Citations Source Cite
Jeremy G. Wideman11
Estimated H-index: 11
(University of Exeter),
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University)
Abstract The ER–mitochondria organizing network (ERMIONE) in Saccharomyces cerevisiae is involved in maintaining mitochondrial morphology and lipid homeostasis. ERMES and MICOS are two scaffolding complexes of ERMIONE that contribute to these processes. ERMES is ancient but has been lost in several lineages including animals, plants, and SAR (stramenopiles, alveolates and rhizaria). On the other hand, MICOS is ancient and has remained present in all organisms bearing mitochondrial cristae. The E...
19 Citations Source Cite
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