Jeremy G. Wideman
Dalhousie University
29Publications
12H-index
315Citations
Publications 29
Newest
Published on Feb 1, 2019in Biology and Philosophy 1.31
Jeremy G. Wideman12
Estimated H-index: 12
(Dalhousie University),
S. Andrew Inkpen2
Estimated H-index: 2
(Dalhousie University)
+ 1 AuthorsRosemary J. Redfield31
Estimated H-index: 31
(University of British Columbia)
Koonin, in an article in this issue, claims that CRISPR–Cas systems are mechanisms for the inheritance of acquired adaptive characteristics, and that the operation of such systems comprises a “Lamarckian mode of evolution.” We argue that viewing the CRISPR–Cas mechanism as facilitating a form of “directed mutation” more accurately represents how the system behaves and the history of neoDarwinian thinking, and is to be preferred.
2 Citations Source Cite
Published on Mar 1, 2019in Nature Ecology and Evolution
Maureen A. O’Malley10
Estimated H-index: 10
(University of Bordeaux),
Michelle M. Leger6
Estimated H-index: 6
(Spanish National Research Council)
+ 1 AuthorsIñaki Ruiz-Trillo28
Estimated H-index: 28
(University of Barcelona)
Insight into the last eukaryotic common ancestor (LECA) is central to any phylogeny-based reconstruction of early eukaryotic evolution. Increasing amounts of data enable such reconstructions, without necessarily providing further insight into what LECA actually was. We consider four possible concepts of LECA: an abstract phylogenetic state, a single cell, a population, and a consortium of organisms. We argue that the view most realistically underlying work in the field is that of LECA as a popul...
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Published on Jun 1, 2018in Fungal Genetics and Biology 3.48
André Luiz Gomes-Vieira2
Estimated H-index: 2
(Universidade Federal Rural do Rio de Janeiro),
Jeremy G. Wideman12
Estimated H-index: 12
(University of Exeter)
+ 3 AuthorsJosé Roberto Meyer-Fernandes29
Estimated H-index: 29
(Federal University of Rio de Janeiro)
Abstract The model yeast Saccharomyces cerevisiae elicits a transcriptional response to phosphate (P i ) depletion. To determine the origins of the phosphate response (PHO) system, we bioinformatically identified putative PHO components in the predicted proteomes of diverse fungi. Our results suggest that the PHO system is ancient; however, components have been expanded or lost in different fungal lineages. To show that a similar physiological response is present in deeply-diverging fungi we exa...
2 Citations Source Cite
Published on Jul 16, 2018in F1000Research
Jeremy G. Wideman12
Estimated H-index: 12
(University of Exeter),
Dario L. Balacco1
Estimated H-index: 1
(University of Nottingham)
+ 1 AuthorsThomas A. Richards33
Estimated H-index: 33
(University of Exeter)
Authors of a recent paper demonstrate that, like ERMES (ER-mitochondria encounter structure) in fungal cells, PDZD8 (PDZ domain containing 8) tethers mitochondria to the ER in mammalian cells. However, identifying PDZD8 as a “functional ortholog” of yeast Mmm1 (maintenance of mitochondrial morphology protein 1) is at odds with the phylogenetic data. PDZD8 and Mmm1 are paralogs, not orthologs, which affects the interpretation of the data with respect to the evolution of ER-mitochondria tethering....
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Published on Feb 5, 2018in Journal of Cell Biology 8.78
Sevan Mattie3
Estimated H-index: 3
(Montreal Neurological Institute and Hospital),
Jan Riemer26
Estimated H-index: 26
(University of Cologne)
+ 1 AuthorsHeidi M. McBride44
Estimated H-index: 44
(Montreal Neurological Institute and Hospital)
Mitochondrial fusion occurs in many eukaryotes, including animals, plants, and fungi. It is essential for cellular homeostasis, and yet the underlying mechanisms remain elusive. Comparative analyses and phylogenetic reconstructions revealed that fungal Fzo1 and animal Mitofusin proteins are highly diverged from one another and lack strong sequence similarity. Bioinformatic analysis showed that fungal Fzo1 proteins exhibit two predicted transmembrane domains, whereas metazoan Mitofusins contain o...
18 Citations Source Cite
Published on Dec 1, 2018in BMC Biology 5.77
Markéta Petrů1
Estimated H-index: 1
(Charles University in Prague),
Jeremy G. Wideman12
Estimated H-index: 12
(Dalhousie University)
+ 3 AuthorsPavel Doležal16
Estimated H-index: 16
(Charles University in Prague)
Background Bacteria and mitochondria contain translocases that function to transport proteins across or insert proteins into their inner and outer membranes. Extant mitochondria retain some bacterial-derived translocases but have lost others. While BamA and YidC were integrated into general mitochondrial protein transport pathways (as Sam50 and Oxa1), the inner membrane TAT translocase, which uniquely transports folded proteins across the membrane, was retained sporadically across the eukaryote ...
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Published on Jan 1, 2018in Open Biology 3.29
Guy Leonard1
Estimated H-index: 1
(University of Exeter),
Aurélie Labarre1
Estimated H-index: 1
(University of Exeter)
+ 14 AuthorsXavier Grau-Bové7
Estimated H-index: 7
(Spanish National Research Council)
Eukaryotic microbes have three primary mechanisms for obtaining nutrients and energy: phagotrophy, photosynthesis and osmotrophy. Traits associated with the latter two functions arose independently multiple times in the eukaryotes. The Fungi successfully coupled osmotrophy with filamentous growth, and similar traits are also manifested in the Pseudofungi (oomycetes and hyphochytriomycetes). Both the Fungi and the Pseudofungi encompass a diversity of plant and animal parasites. Genome-sequencing ...
2 Citations Source Cite
Published on Nov 1, 2018in Current Biology 9.25
Jeremy G. Wideman12
Estimated H-index: 12
(Dalhousie University),
Sergio A. Muñoz-Gómez6
Estimated H-index: 6
(Dalhousie University)
Summary The MICOS complex is conserved across eukaryotes, but little is known about it outside the group that comprises animals and fungi. A new study finds that mitochondria of trypanosomatid parasites bear a divergent MICOS with both ancestral and derived subunits, but with conserved functions in crista development and membrane contact-site formation.
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Published on Apr 14, 2017in Microbiology spectrum
Thomas A. Richards33
Estimated H-index: 33
(University of Exeter),
Guy Leonard13
Estimated H-index: 13
(University of Exeter),
Jeremy G. Wideman12
Estimated H-index: 12
(University of Exeter)
It is a certainty that the tree of life can be broken up into large units of biodiversity that span such great evolutionary distances that one could call them kingdoms. However, if these units are to have any meaning, they must represent radiations of diverse groups underpinned by unique shared derived adaptations that drove the evolutionary success of each group. Without such evolutionary characters, these classifications are merely abstract concepts or arbitrarily demarcated lineages. Even the...
5 Citations Source Cite
Published on Jul 1, 2017in Mechanisms of Development 1.90
Alexander Eve (University of Exeter), Joshua Donnelly (University of Exeter)+ 3 AuthorsPhilip W. Ingham72
Estimated H-index: 72
(University of Exeter)
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