Decoding non-random mutational signatures at Cas9 targeted sites
Abstract
The mutation patterns at Cas9 targeted sites contain unique information regarding the nuclease activity and repair mechanisms in mammalian cells. However, analytical framework for extracting such information are lacking. Here, we present a novel computational platform called Rational InDel Meta-Analysis (RIMA) that enables an in-depth comprehensive analysis of Cas9-induced genetic alterations, especially InDels mutations. RIMA can be used to...
Paper Details
Title
Decoding non-random mutational signatures at Cas9 targeted sites
Published Date
Jul 19, 2018
Journal
Volume
46
Issue
16
Pages
8417 - 8434
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