TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy
Abstract
T cells engineered to express chimeric antigen receptors (CARs) against B cell antigens are being investigated as cellular immunotherapies. Similar approaches designed to target T cell malignancies have been hampered by the critical issue of T-on-T cytotoxicity, whereby fratricide or self-destruction of healthy T cells prohibits cell product manufacture. To date, there have been no reports of T cells engineered to target the definitive T cell...
Paper Details
Title
TCRαβ/CD3 disruption enables CD3-specific antileukemic T cell immunotherapy
Published Date
Jul 12, 2018
Journal
Volume
3
Issue
13
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