Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
Abstract
Asthma and allergy affect hundreds of millions of people from childhood to old age. In most of them, the inflammatory process of respiratory allergies involves the participation of type 2 cytokines, derived from T helper-2 (Th2)-cell, and Group 2 Innate Lymphoid (ILC2) Cells. An efficient memory Th2 cell response is dependent on IL-13 produced by ILC2s, causing allergic lung inflammation and elevated serum levels of immunoglobulin E. ILC2 cells...
Paper Details
Title
Genetic variants in RORA are associated with asthma and allergy markers in an admixed population
Published Date
Jan 1, 2019
Journal
Volume
113
Pages
177 - 184
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