Papers 8767
1 page of 877 pages (8,767 results)
Published on Jan 1, 2020in Cytokine3.08
Abstract Intercellular adhesion molecule 1 (ICAM-1) is a glycoprotein that participates in inflammatory and immune responses. Both cell surface and soluble ICAM-1 are significantly increased during human immunodeficiency virus (HIV) infection, and ICAM-1 has important functions in promoting inflammatory responses and enhancing HIV infectivity; however, a comprehensive summary these roles has yet to be elaborated. In this review we describe the general biological characteristics of ICAM-1, its as...
Published on 2020in Cytokine3.08
Weifeng Mao3
Estimated H-index: 3
(Nantong University),
Xin Yi5
Estimated H-index: 5
(Nantong University)
+ 2 AuthorsGuohua Jin13
Estimated H-index: 13
(Nantong University)
Abstract To investigate the effect of CXCL12 on regeneration of radial glia like cells after traumatic brain injury (TBI). We randomly divided 48 rats into 4 groups: (1) the sham group, rats were performed craniotomy only, (2) the control group, saline were injected into the ipsilateral cortex after TBI, (3) the CXCL12 group, CXCL12 were injected, and (4) the CXCL12 + AMD3100 group, a mixture of CXCL12 and AMD3100 were injected. Seven days after TBI, the brain tissues were subjected to immunoflu...
Published on Jan 1, 2020in Cytokine3.08
Fang-Ling Zhang (Southern Medical University), Bo-Wei Zhou (Southern Medical University)+ 5 AuthorsKe-Xuan Liu3
Estimated H-index: 3
(Southern Medical University)
Abstract Background Sepsis is a major cause of death for ICU patients. Sepsis development depends heavily on the presence of mature IL-1β cytokine. This study evaluates the potential therapeutic properties of a bioactive compound known as 6-gingerol on sepsis. This compound has previously been demonstrated to possess anti-inflammatory properties both in vivo and in vitro. Methods C57BL/6 mice was used to establish models of sepsis by means of cecal ligation and puncture (CLP). Upon treatment wit...
Published on 2020in Cytokine3.08
Daoyuan Gong1
Estimated H-index: 1
(FOSU: Foshan University),
Yunuo Wang (SYSU: Sun Yat-sen University)+ 6 AuthorsShuhong Luo (FOSU: Foshan University)
Abstract Prostate cancer (CaP) is a common male malignancy. Using prostate specific antigen (PSA) and prostate cancer antigen 3 (PCA3) in the diagnosis of prostate cancer, sensitivity and specificity still require improvement. Additional targets are urgently needed for the diagnosis, prognosis, and prediction of therapeutic response, leading to better treatments in order to reduce the mortality of CaP. Here, we utilized a solid-phase antibody array, which can simultaneously detect 200 proteins, ...
Published on Jan 1, 2020in Cytokine3.08
Samantha Simpson (Yale University), Janina Kaislasuo (Yale University)+ 1 AuthorsLubna Pal22
Estimated H-index: 22
(Yale University)
Abstract Background The role of cytokines in various disease states is a burgeoning field of academic study and clinical application, however there are no consensus documents on how certain cytokines should be stored prior to quantification. This information is especially of interest to researchers assembling a biobank or clinicians who have to transport specimens to a different location in order to be tested. Objective To review the literature and synthesize prior findings on cytokine storage a...
Published on 2020in Cytokine3.08
M.S.M.A. Damen3
Estimated H-index: 3
Dov B. Ballak4
Estimated H-index: 4
(CU: University of Colorado Boulder)
+ 5 AuthorsLeo A. B. Joosten81
Estimated H-index: 81
Abstract Low-grade inflammation is associated with the development of insulin resistance in obese individuals. The present study aims to provide additional evidence strengthening the role of interleukin (IL)-32 in this key process. Using an IL-32 transgenic (IL-32tg) mouse model, we observed that IL-32tg fed a normal diet had greater body weight, due to greater accumulation of white adipose tissue (WAT) along with larger sized adipocytes. This led to metabolic consequences, with significant high...
Published on Jan 1, 2020in Cytokine3.08
Smriti K. Raychaudhuri21
Estimated H-index: 21
Christine Abria3
Estimated H-index: 3
+ 1 AuthorsSiba P. Raychaudhuri32
Estimated H-index: 32
(UC Davis: University of California, Davis)
Abstract Background Mucosal-associated invariant T (MAIT) cells are gaining more relevance for autoimmune diseases because of its (i) innate and adaptive immune response (ii) tissue homing properties (iii) production of IL-17A. These cells are predominantly CD8+ cells, because of its strong association with MHC-I. Tc17 CD8+/MAIT cells likely to have a critical role in psoriatic arthritis (PsA). Herein, we have explored pathological significance of MAIT cell in PsA. Methods Peripheral blood monon...
Published on 2020in Cytokine3.08
Basim Askar2
Estimated H-index: 2
(University of Nottingham),
John Higgins3
Estimated H-index: 3
(University of Nottingham)
+ 1 AuthorsNeil Foster17
Estimated H-index: 17
(University of Nottingham)
Abstract Studies have shown that administration of vasoactive intestinal peptide (VIP) in mice rescues them from lethal endotoxaemia and that this is correlated with decreased concentration of inflammatory cytokines. VIP has, therefore, been proposed as a novel anti-inflammatory which could be used in the treatment of Gram negative sepsis. However, the effect of VIP has not been reported in mice infected with viable Gram negative bacteria. Here, we show that Salmonella enterica serovar Typhimuri...
Published on Jan 1, 2020in Cytokine3.08
Linda K. Wijaya5
Estimated H-index: 5
(Murdoch University),
Philip A. Stumbles26
Estimated H-index: 26
(Murdoch University),
Peter D. Drummond45
Estimated H-index: 45
(Murdoch University)
Abstract Keratinocytes produce cytokines and nerve growth factor (NGF) as part of a repair response to injury, disease or stress, and express alpha1-adrenoceptors (α1-AR). The expression of these receptors is elevated in some inflammatory diseases and chronic pain conditions. In this study, we investigated whether inflammatory signalling affects α1-AR expression in keratinocytes in vitro. Tumor necrosis factor α (TNFα) was administered to human keratinocytes, after which the levels of other key ...
Published on Jan 1, 2020in Cytokine3.08
Carlota Dobaño25
Estimated H-index: 25
(University of Barcelona),
Azucena Bardají23
Estimated H-index: 23
(University of Barcelona)
+ 18 AuthorsMyriam Arévalo-Herrera33
Estimated H-index: 33
Abstract The immune status of women changes during and after pregnancy, differs between blood compartments at delivery and is affected by environmental factors particularly in tropical areas endemic for multiple infections. We quantified the plasma concentration of a set of thirty-one TH1, TH2, TH17 and regulatory cytokines, pro-inflammatory and anti-inflammatory cytokines and chemokines, and growth factors (altogether biomarkers), in a cohort of 540 pregnant women from five malaria-endemic trop...