Review paper
Functional Genomics via CRISPR–Cas
Abstract
RNA-guided CRISPR (clustered regularly interspaced short palindromic repeat)-associated Cas proteins have recently emerged as versatile tools to investigate and engineer the genome. The programmability of CRISPR–Cas has proven especially useful for probing genomic function in high-throughput. Facile single-guide RNA library synthesis allows CRISPR–Cas screening to rapidly investigate the functional consequences of genomic, transcriptomic, and...
Paper Details
Title
Functional Genomics via CRISPR–Cas
Published Date
Jan 1, 2019
Journal
Volume
431
Issue
1
Pages
48 - 65
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