Designing of membrane-active nano-antimicrobials based on cationic copolymer functionalized nanodiamond: Influence of hydrophilic segment on antimicrobial activity and selectivity

Designing cationic nano-antimicrobial is a promising solution for combating drug resistant microbes. In this work, hydrophilic cationic copolymer was applied for the surface functionalization of nanodiamonds (NDs) aiming at developing a highly membrane-active nano-antibacterial agent with satisfactory selectivity. As a result, after functionalization, the increased repulsive forces within NDs and interaction with solvent molecular network made...