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Materials Science and Engineering: C
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Abstract Resorbable biomaterials based on artificial extracellular matrices (aECM) represent promising scaffolds for the treatment of large bone defects. Here, we investigated various glycosaminoglycan (GAG) derivatives of varying sulfation degree with respect to their influence on in vivo bone healing. The materials used in this study consisted of GAG-coated degradable polycaprolactone-co-lactide (PCL). Critical size femur defects in rats were filled with autologous bone serving as positive con...
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#1Kamal Hany Hussein (Assiut University)H-Index: 8
#2Kyung-Mee Park (CBNU: Chungbuk National University)H-Index: 2
Last. Heung-Myong Woo (Kangwon National University)H-Index: 15
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Abstract Liver fibrosis results from excessive accumulation of extracellular matrix (ECM) proteins that distort the hepatic architecture. Progression of liver fibrosis results in cirrhosis and liver failure, and often, liver transplantation is required. The decellularized liver tissue contains different components that mimic the natural hepatic environment. We hypothesized that a decellularized liver hydrogel can be used to replace the necrotic hepatocytes and damaged ECM. Therefore, our aim in ...
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#1Xin Li (Katholieke Universiteit Leuven)H-Index: 6
#2Mariano Pedano (Katholieke Universiteit Leuven)H-Index: 4
Last. Bart Van Meerbeek (Katholieke Universiteit Leuven)H-Index: 47
view all 10 authors...
Abstract Objectives To investigate the pulpal repair potential of an experimental zirconium-oxide containing tricalcium-silicate cement, referred to as ‘TCS 50’. Materials and methods The effect of TCS 50 on viability, proliferation, migration, and odontoblastic differentiation of human dental pulp cells (HDPCs) was assessed using XTT assay, in-vitro wound healing assay and RT-PCR, respectively. Additionally, the pulp-capping potential was evaluated using a vital human tooth model. Statistical a...
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#1Shiv Dutt Purohit (IITR: Indian Institute of Technology Roorkee)H-Index: 1
#2Hemant Singh (IITR: Indian Institute of Technology Roorkee)H-Index: 10
Last. Narayan C. Mishra (IITR: Indian Institute of Technology Roorkee)H-Index: 11
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Abstract Worldwide the number of bone damage/fracture, due to traumatic and accidental injuries, has been growing exponentially. Currently available treatments for bone repairing are slow, and often full functional recovery is not achieved. During slow healing process, free radicals are generated at fractured site, which causes further delay in healing process. To overcome these problems, bone tissue engineering (BTE) based approaches, i.e., polymeric scaffolds loaded with free radical scavengin...
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Abstract Posttraumatic peritendinous adhesion leads to limb disability. Physical barrier was widely used and thus focus was paid to fabricate the hydrophobic surfaces of electrospun membrane for anti-adhesion. However, current methods are limited and complicated. In this study, beeswax (Wax)/poly-L-lactic acid (PLA) anti-adhesion membranes were fabricated by blending electrospinning of Wax and PLA. The water contact angle was tested to investigate the hydrophobicity of the surfaces. Incorporatio...
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Abstract Exclusive magnetocaloric properties of orthoferrites offer advantages for their application in the magnetic hyperthermia as well as imaging applications. In the present study, the effect of yttrium concentration on the magnetic characteristics of the iron oxide based nanomaterials was analyzed to assess their potential for the hyperthermia applications. The Sol-gel method was used to synthesize the Yttrium Iron Garnet (YIG) based nanoparticles, using different molar ratios of Fe and Y p...
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#1M.W. Vaughan (A&M: Texas A&M University)H-Index: 4
#2A.I. Karayan (A&M: Texas A&M University)
Last. Hans Jürgen Maier (Leibniz University of Hanover)H-Index: 50
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Abstract In this work, a bioresorbable Mg-ZKQX6000 (Mg–6Zn–0.6Zr–0.4Ag–0.2Ca (wt%)) alloy was severely plastically deformed via equal channel angular pressing (ECAP) according to three unique hybrid routes at low temperatures (200 °C to 125 °C). The roles of ECAP processing on microstructure, and ensuing mechanical properties and corrosion rates, are assessed. Microstructurally, ECAP induces a complex plethora of features, especially variations in grain sizes and precipitates' sizes, distributio...
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#1Caitlin Koski (WSU: Washington State University)H-Index: 1
#2Ashley A. Vu (WSU: Washington State University)H-Index: 2
Last. Susmita Bose (WSU: Washington State University)H-Index: 60
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Abstract Osteosarcoma remains one of the most common malignant primary bone tumors. Post-surgical defect repair combined with tumor suppression remains a major clinical challenge. Investigations of alternative treatments for osteosarcoma, while promising, have led to multi-drug resistance. These constraints of common treatment strategies have triggered the need for new therapeutic candidates in bone cancer treatment. Chitosan, a common biopolymer utilized in bone and tissue engineering applicati...
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Abstract Nanocomposite materials have been proposed to enhance the properties of different materials. In this study, palygorskite (Pal) clay is proposed as a support matrix for silver nanoparticles stabilised with cashew gum (Anacardium occidentale L.) (AgNPs-CG), producing the Pal/AgNPs-CG nanocomposite, whose bactericidal activity was studied. AgNPs-CG was synthesised using a green method in which CG acted as a reducing and stabilising agent for these nanostructures. AgNPs-CGs were subsequentl...
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#1Joana Vaz-Ramos (UC: University of Coimbra)
#2Rosemeyre A. Cordeiro (UC: University of Coimbra)H-Index: 6
Last. Luísa Durães (UC: University of Coimbra)H-Index: 18
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Abstract Mesoporous silica nanoparticles with a superparamagnetic iron oxide core were prepared in this work, in order to obtain multifunctional platforms with adequate features for cancer theranostics. Three different core-shell nanocomplexes were obtained: IO-OAm/mSiO2, IO-APTES/mSiO2 and IO/SiO2/mSiO2. In the case of IO-OAm/mSiO2 and IO-APTES/mSiO2, iron oxide (IO) was obtained by thermal decomposition, having in this case a coating of oleylamine (OAm) that was in the second formulation excha...
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