Quantitative path to deep phenotyping: Possible importance of reduced hepatic insulin degradation to type 2 diabetes mellitus pathogenesis

Diabetes is often thought of as one of two diseases: type 1 diabetes mellitus (T1DM), which is caused by immunological destruction of the β-cells, and type 2 diabetes mellitus (T2DM), which is due to a combination of insulin resistance and relative failure of the β-cells to compensate for the resistance. However, it is becoming clear that even within these two definitions there may be considerable heterogeneity.1 There are several approaches to...