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Marilyn Ader
Cedars-Sinai Medical Center
55Publications
28H-index
4,433Citations
Publications 55
Newest
#1Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 103
#2Francesca Piccinini (Cedars-Sinai Medical Center)H-Index: 3
Last.Marilyn Ader (Cedars-Sinai Medical Center)H-Index: 28
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Abstract Malfunction of the liver is a central factor in metabolic disease. Glucose production by liver is complex and controlled via indirect mechanisms; insulin regulates adipose tissue lipolysis, and free fatty acids in turn regulate liver glucose output. This latter concept is confirmed by studies in L-Akt-Foxo1 knockout mice. The adipocyte is a likely locus of hepatic insulin resistance. Also, kidneys play a role in regulating glucose production; denervated kidneys abrogate the effect of fa...
#1Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 103
#2Francesca Piccinini (Cedars-Sinai Medical Center)H-Index: 3
Last.Marilyn Ader (Cedars-Sinai Medical Center)H-Index: 28
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There is wide variance among individuals in the fraction of insulin cleared by the liver (20% to 80%). Hepatic insulin clearance is 67% lower in African Americans than European Americans. Clearance is also lower in African American children 7–13 years of age. Lower hepatic insulin clearance will result in peripheral hyperinsulinemia: this exacerbates insulin resistance, which stresses the β-cells, possibly resulting in their ultimate failure and onset of type 2 diabetes. We hypothesize that lowe...
#1Orison O. Woolcott (Cedars-Sinai Medical Center)H-Index: 9
#2Marilyn Ader (Cedars-Sinai Medical Center)H-Index: 28
Last.Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 103
view all 3 authors...
Most of the literature related to high altitude medicine is devoted to the short-term effects of high-altitude exposure on human physiology. However, long-term effects of living at high altitudes may be more important in relation to human disease because more than 400 million people worldwide reside above 1500 m. Interestingly, individuals living at higher altitudes have a lower fasting glycemia and better glucose tolerance compared with those who live near sea level. There is also emerging evid...
#1Ana Valeria B. Castro (Cedars-Sinai Medical Center)H-Index: 10
#2Orison O. Woolcott (Cedars-Sinai Medical Center)H-Index: 9
Last.Isaac Asare-Bediako (Cedars-Sinai Medical Center)H-Index: 2
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Objectives To determine whether a selective increase of visceral adipose tissue content will result in insulin resistance. Methods Sympathetic denervation of the omental fat was performed under general inhalant anesthesia by injecting 6-hydroxydopamine in the omental fat of lean mongrel dogs (n = 11). In the conscious animal, whole-body insulin sensitivity was assessed by the minimal model (SI) and the euglycemic hyperinsulinemic clamp (SICLAMP). Changes in abdominal fat were monitored by magnet...
#1Marilyn Ader (Cedars-Sinai Medical Center)H-Index: 28
#2Darko Stefanovski (Cedars-Sinai Medical Center)H-Index: 17
Last.Richard N. Bergman (Cedars-Sinai Medical Center)H-Index: 103
view all 8 authors...
Accurate quantification of insulin resistance is essential for determining efficacy of treatments to reduce diabetes risk. Gold-standard methods to assess resistance are available (e.g., hyperinsulinemic clamp or minimal model), but surrogate indices based solely on fasting values have attractive simplicity. One such surrogate, the homeostatic model assessment of insulin resistance (HOMA-IR), is widely applied despite known inaccuracies in characterizing resistance across groups. Of greater sign...
#1Marilyn Ader (Cedars-Sinai Medical Center)H-Index: 28
#2Darko Stefanovski (Cedars-Sinai Medical Center)H-Index: 17
Last.Hsu Ir (Cedars-Sinai Medical Center)H-Index: 1
view all 10 authors...
Objective Insulin resistance is a powerful risk factor for Type 2 diabetes and a constellation of chronic diseases, and is most commonly associated with obesity. We examined if factors other than obesity are more substantial predictors of insulin sensitivity under baseline, nonstimulated conditions. Methods Metabolic assessment was performed in healthy dogs (n = 90). Whole-body sensitivity from euglycemic clamps (SICLAMP) was the primary outcome variable, and was measured independently by IVGTT ...
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