Optimized base editors enable efficient editing in cells, organoids and mice
Abstract
CRISPR base editing enables the creation of targeted single-base conversions without generating double-stranded breaks. However, the efficiency of current base editors is very low in many cell types. We reengineered the sequences of BE3, BE4Gam, and xBE3 by codon optimization and incorporation of additional nuclear-localization sequences. Our collection of optimized constitutive and inducible base-editing vector systems dramatically improves the...
Paper Details
Title
Optimized base editors enable efficient editing in cells, organoids and mice
Published Date
Oct 1, 2018
Journal
Volume
36
Issue
9
Pages
888 - 893
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