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Mesenteric adipose tissue contributes to intestinal barrier integrity and protects against nonalcoholic fatty liver disease in mice

Published on Nov 1, 2018in American Journal of Physiology-gastrointestinal and Liver Physiology 3.29
· DOI :10.1152/ajpgi.00079.2018
Zhe Wu2
Estimated H-index: 2
(PKU: Peking University),
Jiang Tan (PKU: Peking University)+ 6 AuthorsYulan Liu7
Estimated H-index: 7
(PKU: Peking University)
The mesenteric adipose tissue (MAT) lies between the gut and liver and plays a critical role in hepatic metabolic diseases. In the present study, we found that the MAT was prone to inflammation in ...
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Published on Dec 1, 2018in Scientific Reports 4.12
Inmaculada García-Ruiz11
Estimated H-index: 11
(Complutense University of Madrid),
Pablo Solís-Muñoz12
Estimated H-index: 12
(University of Cambridge)
+ 3 AuthorsJosé A. Solís-Herruzo22
Estimated H-index: 22
(Complutense University of Madrid)
Visceral fat deposition is associated with impairment of glucose and lipid metabolism while leptin levels are frequently related to subcutaneous fat area. At present, there is considerable controversy regarding the role of visceral adipose tissue accumulation in the development of metabolic syndrome (MS). Here we show the effects of omentectomy on the liver and MS in a diet induced obesity rat model. Our results reveal that undergoing omentectomy previously the establishment of the diet-induced-...
2 Citations Source Cite
Published on Dec 1, 2017in Inflammation 2.88
Lijun Dong1
Estimated H-index: 1
(Xinxiang Medical University),
Yao Zhang1
Estimated H-index: 1
(Xinxiang Medical University)
+ 3 AuthorsHui Wang11
Estimated H-index: 11
(Xinxiang Medical University)
T cells are involved in chronic inflammation of adipose tissue in obese conditions. However, the impact of age on the adipose T cells remains unknown. In this study, we investigated T cells in the white adipose tissue of young and adult mice. Obesity was induced in the mice using a high-fat diet (HFD) for 14 weeks. The young mice were fed an HFD at 3 weeks old, and adult mice were fed the HFD at 12 weeks old. Relative to adult mice, the young mice gained less fat and exhibited better glucose tol...
5 Citations Source Cite
Published on Nov 23, 2017in The New England Journal of Medicine 79.26
Anna Mae Diehl98
Estimated H-index: 98
Christopher P. Day82
Estimated H-index: 82
Nonalcoholic steatohepatitis is a major cause of cirrhosis and liver cancer. It is associated with visceral adiposity and the metabolic syndrome and is nearly as common as type 2 diabetes. Metabolic stress, inflammation, and fibrosis are the primary pathogenic mechanisms.
95 Citations Source Cite
Published on Jun 1, 2017in Gut 17.02
Leon A. Adams33
Estimated H-index: 33
(UWA: University of Western Australia),
Quentin M. Anstee39
Estimated H-index: 39
(Newcastle University)
+ 1 AuthorsGiovanni Targher58
Estimated H-index: 58
Key physiological functions of the liver, including glucose and lipid metabolism, become disturbed in the setting of non-alcoholic fatty liver disease (NAFLD) and may be associated with a systemic inflammatory ‘ milieu ’ initiated in part by liver-secreted cytokines and molecules. Consequently, the pathophysiological effects of NAFLD extend beyond the liver with a large body of clinical evidence demonstrating NAFLD to be independently associated with both prevalent and incident cardiovascular di...
117 Citations Source Cite
Published on Dec 1, 2016in Diabetology & Metabolic Syndrome 2.41
Esteban Jorge-Galarza11
Estimated H-index: 11
Aida Medina-Urrutia13
Estimated H-index: 13
+ 7 AuthorsJuan Gabriel Juárez-Rojas12
Estimated H-index: 12
To evaluate the role of adipose tissue function on the association of fatty liver (FL) with impaired fasting glucose (IFG) or newly diagnosed type 2 diabetes mellitus (nT2D). In 1264 subjects, computed tomography was used to evaluate FL and elevated visceral adipose tissue (VAT). Fasting plasma glucose, <5.6, 5.6–6.9 and ≥7 mmol/l, were used to defined normoglycemic (NG), IFG or nT2D, respectively. Elevated free fatty acids, low serum adiponectin levels and adipose tissue insulin resistance (Adi...
4 Citations Source Cite
Published on Jul 1, 2016in Nature Reviews Gastroenterology & Hepatology 17.32
Christopher Leung7
Estimated H-index: 7
Leni R. Rivera14
Estimated H-index: 14
+ 1 AuthorsPeter W Angus44
Estimated H-index: 44
This Review discusses the mechanisms via which changes in the gut can influence the development and progression of NAFLD. Understanding of such mechanisms is hoped to pave the way for new treatments for what has become the most common form of liver disease.
129 Citations Source Cite
Published on Jun 1, 2016in Inflammatory Bowel Diseases 4.35
Yi Li1
Estimated H-index: 1
(NU: Nanjing University),
Weiming Zhu21
Estimated H-index: 21
(NU: Nanjing University)
+ 1 AuthorsBo Shen49
Estimated H-index: 49
(Cleveland Clinic)
17 Citations Source Cite
Published on Apr 1, 2016in International Journal of Obesity 5.16
Petra Mulder8
Estimated H-index: 8
Martine C. Morrison11
Estimated H-index: 11
+ 3 AuthorsRobert Kleemann11
Estimated H-index: 11
Background: Non-alcoholic fatty liver disease (NAFLD) is strongly associated with abdominal obesity. Growing evidence suggests that inflammation in specific depots of white adipose tissue (WAT) has a key role in NAFLD progression, but experimental evidence for a causal role of WAT is lacking. Methods: A time-course study in C57BL/6J mice was performed to establish which WAT depot is most susceptible to develop inflammation during high-fat diet (HFD)-induced obesity. Crown-like structures (CLS) w...
30 Citations Source Cite
Published on Feb 1, 2016in Cell Host & Microbe 17.87
Lirui Wang10
Estimated H-index: 10
(UCSD: University of California, San Diego),
Derrick E. Fouts35
Estimated H-index: 35
(JCVI: J. Craig Venter Institute)
+ 9 AuthorsDavid A. Brenner110
Estimated H-index: 110
(UCSD: University of California, San Diego)
Approximately half of all deaths from liver cirrhosis, the tenth leading cause of mortality in the United States, are related to alcohol use. Chronic alcohol consumption is accompanied by intestinal dysbiosis and bacterial overgrowth, yet little is known about the factors that alter the microbial composition or their contribution to liver disease. We previously associated chronic alcohol consumption with lower intestinal levels of the antimicrobial-regenerating islet-derived (REG)-3 lectins. Her...
74 Citations Source Cite
Published on Dec 1, 2015in Medicine 2.03
Su Jong Yu19
Estimated H-index: 19
Won-Seog Kim69
Estimated H-index: 69
+ 8 AuthorsYoon Jun Kim36
Estimated H-index: 36
Nonalcoholic fatty liver disease (NAFLD) is associated with visceral obesity. However, the association between visceral adipose tissue (VAT) area and fibrosis in NAFLD patients has not been completely established. This study was aimed to determine the relationship between the computed tomography-measured VAT area and significant fibrosis in NAFLD patients. A total of 324 NAFLD patients and 132 controls were evaluated by liver biopsy. NAFLD was diagnosed based on histological examinations and alc...
24 Citations Source Cite
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