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Yulan Liu
Peking University
25Publications
7H-index
485Citations
Publications 25
Newest
#1Tingting WangH-Index: 1
Last.Yulan Liu (PKU: Peking University)H-Index: 7
view all 10 authors...
Background Ulcerative colitis (UC) is characterized by chronic inflammation in the colon and epigenetic factors underlying the occurrence. Circular RNAs (circRNAs) have been under intensive focus due to the circular construct and gene-regulating functions. However, the changes and roles of circRNAs in UC remain unknown.
#1Zhe Wu (PKU: Peking University)H-Index: 2
#2Jun Xu (PKU: Peking University)H-Index: 1
Last.Yujing Chi (PKU: Peking University)H-Index: 3
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#1Lin Su (PKU: Peking University)
#2Zhe Wu (PKU: Peking University)H-Index: 2
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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Abstract Non-alcoholic fatty liver disease (NAFLD) is characterized by altered intestinal microbiota and intestinal immune disorder. Here we investigated the role of mesenteric lymph node (MLN) CD4 + T lymphocytes in NAFLD. In high fat diet (HFD)-fed mice, the percentage ratios of Th1 to Th2 cells and Th17 to Treg cells were imbalanced in MLNs. Co-culture assays showed MLN CD4 + T lymphocytes from HFD-fed mice tended to migrate to the liver and promoted hepatic inflammation. Adoptive transfer of...
#1Zhe Wu (PKU: Peking University)H-Index: 2
#2Jiang Tan (PKU: Peking University)
Last.Yulan Liu (PKU: Peking University)H-Index: 7
view all 9 authors...
The mesenteric adipose tissue (MAT) lies between the gut and liver and plays a critical role in hepatic metabolic diseases. In the present study, we found that the MAT was prone to inflammation in ...
#1Jun Xu (PKU: Peking University)H-Index: 1
#2Ning Chen (PKU: Peking University)H-Index: 1
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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Background The aim of this study was to clarify the effect of 5-aminosalicylic acid (5-ASA) treatment on gut bacterial microbiota in patients with ulcerative colitis (UC). Methods A total of 57 UC patients, including 20 untreated and 37 5-ASA-treated, were recruited into an exploration cohort. We endoscopically collected both noninflamed and inflamed mucosal samples from all patients, and compared the gut bacterial profiles using 16S rDNA sequencing. Ten untreated UC patients were then treated w...
#1Yu-Jun Zhang (PKU: Peking University)H-Index: 1
#2Ying Hu (PKU: Peking University)H-Index: 4
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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Background The integrative analysis of microRNA and mRNA expression profiles can elucidate microRNA-targeted gene function. We used this technique to elucidate insights into the immunological pathology of non-alcoholic fatty liver disease (NAFLD). Methods We analyzed differentially expressed microRNA and mRNA expression profiles of CD4 + T lymphocytes from the liver and mesenteric lymph nodes (MLNs) of mice with NAFLD using microarrays and RNA sequencing. Normal mice were used as controls. The t...
#1Yongfei Hu (CAS: Chinese Academy of Sciences)H-Index: 21
#2Xi Yang (CAS: Chinese Academy of Sciences)H-Index: 15
Last.GeorgeFGao (CAS: Chinese Academy of Sciences)H-Index: 67
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ABSTRACT Horizontally acquired antibiotic resistance genes (ARGs) in bacteria are highly mobile and have been ranked as principal risk resistance determinants. However, the transfer network of the mobile resistome and the forces driving mobile ARG transfer are largely unknown. Here, we present the whole profile of the mobile resistome in 23,425 bacterial genomes and explore the effects of phylogeny and ecology on the recent transfer (≥99% nucleotide identity) of mobile ARGs. We found that mobile...
#1Xinyun Qiu (PKU: Peking University)H-Index: 2
#2Xia Li (PKU: Peking University)H-Index: 2
Last.Yulan Liu (PKU: Peking University)H-Index: 7
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The commensal intestinal microbiota plays critical roles in the development of inflammatory bowel diseases (IBD). However, the importance of intestinal fungi and their interactions with bacteria in the pathogenesis of IBD is unclear. In this study, anti-fungal drugs (fluconazole or amphotericin B [AmpB]) were administered to control mice and those treated, acutely (A-DSS) and chronically (C-DSS) with DSS. The severity of colonic inflammation was assessed, and pro-inflammatory cytokine levels in ...
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