PCSK9 induces a pro-inflammatory response in macrophages
Abstract
Intraplaque release of inflammatory cytokines from macrophages is implicated in atherogenesis by inducing the proliferation and migration of media smooth muscle cells (SMCs). PCSK9 is present and released by SMCs within the atherosclerotic plaque but its function is still unknown. In the present study, we tested the hypothesis that PCSK9 could elicit a pro-inflammatory effect on macrophages. THP-1-derived macrophages and human primary...
Paper Details
Title
PCSK9 induces a pro-inflammatory response in macrophages
Published Date
Feb 2, 2018
Journal
Volume
8
Issue
1
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