Review paper
Emerging therapeutic modalities of PARP inhibitors in breast cancer
Abstract
Inhibition of Poly (ADP-ribose) polymerase (PARP) has shown marked benefit for breast cancer with homologous recombination deficiency, whether driven by defects in BRCA1, BRCA2, or other pathway components. Since the initial approval of olaparib, a mostly investigated PARP inhibitor (PARPi), the clinical development of PARPi in breast cancer treatment has been a major emphasis. Researches in investigating platinum-PARPi combination use compared...
Paper Details
Title
Emerging therapeutic modalities of PARP inhibitors in breast cancer
Published Date
Jul 1, 2018
Journal
Volume
68
Pages
62 - 68
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