A metabolomic study of the effect of Candida albicans glutamate dehydrogenase (GDH2 or GDH3) deletion on growth and morphogenesis

There are two glutamate dehydrogenases in the pathogenic fungus Candida albicans. One is a NAD+-dependent glutamate dehydrogenase (encoded by GDH2) responsible for the catabolism of glutamate into α-ketoglutarate and ammonium. The other is a NADPH-dependent glutamate dehydrogenase (encoded by GDH3) that catalyses the biosynthesis of glutamate from α-ketoglutarate. These two enzymes are part of the nitrogen and nicotinate/nicotinamide metabolic...